Ontology highlight
ABSTRACT:
SUBMITTER: Luo X
PROVIDER: S-EPMC6214875 | biostudies-other | 2018 Dec
REPOSITORIES: biostudies-other
Molecular therapy. Methods & clinical development 20181010
Infection with <i>Schistosoma</i> causes aberrant expression of host microRNAs (miRNAs), and normalizing the levels of dysregulated miRNAs can attenuate pathology. Here, we show that the host miRNA, <i>miR-96</i>, is markedly upregulated during the progression of hepatic schistosomiasis. We demonstrate that elevation of <i>miR-96</i> induces hepatic fibrosis in infected mice by suppressing the expression of its target gene, <i>Smad7</i>. We show that infection with <i>Schistosoma</i> induces the ...[more]