Nanoformulated paclitaxel and AZD9291 synergistically eradicate non-small-cell lung cancers in vivo.
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ABSTRACT:
SUBMITTER: Wang XS
PROVIDER: S-EPMC6219431 | biostudies-other | 2018 May
REPOSITORIES: biostudies-other
Publications
Nanoformulated paclitaxel and AZD9291 synergistically eradicate non-small-cell lung cancers in vivo.
Wang Xin-Shuai XS Zhang Li L Li Xiaocen X Kong De-Jiu DJ Hu Xiao-Chen XC Ding Xue-Zhen XZ Yang Jun-Qiang JQ Zhao Meng-Qi MQ He Yixuan Y Lam Kit S KS Gao She-Gan SG Lin Tzu-Yin TY Li Yuanpei Y
Nanomedicine (London, England) 20180501 10
<h4>Aim</h4>This study aims to develop new nanoformulations of EGFR T790M targeted inhibitor AZD9291 and paclitaxel (PTX) for combination therapy of lung cancer.<h4>Materials & methods</h4>We prepared and characterized PTX- and AZD9291-loaded disulfide cross-linking micelles (DCMs), and evaluate their combination effect and toxicity in vitro and in lung cancer-bearing mice.<h4>Results</h4>Drug-loaded DCMs were relatively small in size, and possessed glutathione-responsive drug release. The combi ...[more]
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