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New Phragmalin-Type Limonoids from Chukrasia tabularis and Their ?-Glucosidase Inhibitory Activity.

ABSTRACT: Phytochemical investigation on the stems of C. tabularis led to the isolation of five new phragmalin-type limonoids and six known ones. The structures of the new compounds 1-5, named chukbularisins A-E, were elucidated by spectroscopic techniques (IR, HRESIMS, 1D and 2D NMR) and comparisons with published data. All the compounds were evaluated for in vitro ?-glucosidase inhibitory activity. Compounds 2, 3, 4, 5, and 8 exhibited inhibitory activity against ?-glucosidase with IC50 values of 0.06 ± 0.008, 0.04 ± 0.002, 0.52 ± 0.039, 1.09 ± 0.040, and 0.20 ± 0.057 mM, respectively (using acarbose as positive control, IC50 0.95 ± 0.092 mM).

SUBMITTER: Peng JL

PROVIDER: S-EPMC6274087 | biostudies-other | 2016 Jan

REPOSITORIES: biostudies-other

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New Phragmalin-Type Limonoids from Chukrasia tabularis and Their α-Glucosidase Inhibitory Activity.

Peng Jun-Lin JL Wang Jun J Kong Fan-Dong FD Liu Zi-Qi ZQ Wang Pei P Gai Cui-Juan CJ Jiang Bei B Mei Wen-Li WL Dai Hao-Fu HF

Molecules (Basel, Switzerland) 20160105 1

Phytochemical investigation on the stems of C. tabularis led to the isolation of five new phragmalin-type limonoids and six known ones. The structures of the new compounds 1-5, named chukbularisins A-E, were elucidated by spectroscopic techniques (IR, HRESIMS, 1D and 2D NMR) and comparisons with published data. All the compounds were evaluated for in vitro α-glucosidase inhibitory activity. Compounds 2, 3, 4, 5, and 8 exhibited inhibitory activity against α-glucosidase with IC50 values of 0.06 ± ...[more]

PMID: 26742029

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