Moxifloxacin: A Cardiovascular Safety Pharmacology Study Using Radiotelemetry in Conscious Cynomolgus Monkeys Following Oral Administration

ABSTRACT: N= 4 male Conscious telemetered Cynomolgus monkeys, dosed successively with moxifloxacine (12.5, 40, 120 mg/kg, p.o.). No PK performed. Parameters: haemodynamic parameters (SAP, DAP, MAP, PAP, HR), lead II ECG (RR, PR, PQ, QT, QRS, QTcv and QTcF intervals), body temperature.All parameters were reported approximately every 15 minutes for a period of 1-hour prior to dosing, and 0.5, 1, 1.5, 2, 3, 4, 6, 8, 12, 16 and 20 hours post-dosing.

ORGANISM(S): Cynomolgus Monkeys

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PROVIDER: S-TQST84 | biostudies-other |

REPOSITORIES: biostudies-other