Genomic

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Integrated Genetic and Pharmacologic Interrogation of Rare Cancers


ABSTRACT:

Due to the paucity of patient derived models in rare cancers, identification of therapeutic targets remains challenging. We developed a patient derived model, CLF-PED-015-T, from a patient with an undifferentiated sarcoma. From this model, we performed pooled RNAi and CRISPR-Cas9 negative selection screens and integrated that with a small molecule screen. Integration of these data identified CDK4 and XPO1 as potential therapeutic targets.

PROVIDER: phs001121 | dbGaP |

SECONDARY ACCESSION(S): PRJNA321575PRJNA321574

REPOSITORIES: dbGaP

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