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Genomics of Pediatric Renal Medullary Carcinomas

ABSTRACT:

We derived faithful cancer cell lines from patients with a diagnosis of renal medullary carcinomas (RMC). These models have been sequenced with whole genome, exome and transcriptome technologies along with the patient's primary germline and tumor samples. We took these faithful models and performed loss-of-function genetic perturbation screens (e.g. RNAi and CRISPR-Cas9) along with an orthogonal small molecule screen. We identified the ubiquitin-proteasome system as an important target in RMC as well as other SMARCB1 deficient cancers.

PROVIDER: phs001800 | dbGaP |

REPOSITORIES: dbGaP

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			Action	DRS
	GapExchange_phs001800.v1.p1.xml	Xml
	dbGaPEx2.1.5.xsd	Other
	Study_Report.phs001800.Pediatric_RMC.v1.p1.MULTI.pdf	Pdf
	manifest_phs001800.Pediatric_RMC.v1.p1.c1.HMB.pdf	Pdf
	manifest_phs001800.Pediatric_RMC.v1.p1.c2.DS-CA-MDS.pdf	Pdf

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