Dataset Information

Fine Mapping of Eight Psoriasis Susceptibility Loci

ABSTRACT:

Psoriasis is a common immune-mediate disease identified through scaly patches of the skin. In this study we collected genotype information on 5,067 samples of European ancestry as a follow-up study of our initial GWAS (Nair et al. 2009). We designed an Illumina iSelect custom genotyping array with 2,269 tagging SNPs in the eight known psoriasis susceptibility regions (MHC, IL12B, IL23R, IL23A, TNFAIP3, IL13, RNF114, and TNIP1). The custom array also included 5,463 SNPs outside the eight known susceptibility regions, which were selected based on their association p-values in a meta-analysis of HapMap-imputed genotypes of two published GWAS-CASP (Nair et al. 2009) and (Ellinghaus et al. 2010). After quality control we analyzed 4,806 samples (2,699 cases and 2,107 controls).

Please note: The accession number for this dbGaP study was incorrectly listed in the relevant publication (Das et al., 2015, Eur. J. Hum. Genet 23:844-853) as phs000019.v1.p1.

PROVIDER: phs001298 | dbGaP |

SECONDARY ACCESSION(S): PRJNA375837PRJNA375838

REPOSITORIES: dbGaP

ACCESS DATA

Dataset's files

Source:

			Action	DRS
	GapExchange_phs001298.v1.p1.xml	Xml
	dbGaPEx2.1.5.xsd	Other
	Study_Report.phs001298.EightPsoriasisSusceptibilityLoci.v1.p1.MULTI.pdf	Pdf
	manifest_phs001298.EightPsoriasisSusceptibilityLoci.v1.p1.c1.GRU-PUB.pdf	Pdf
	manifest_phs001298.EightPsoriasisSusceptibilityLoci.v1.p1.c2.DS-PSO-PSA-PUB.pdf	Pdf

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Dataset Information

Fine Mapping of Eight Psoriasis Susceptibility Loci

Dataset's files

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