Neurotoxic Symptoms in Adjuvant Chemotherapy in Patients With Colorectal Cancer
Ontology highlight
ABSTRACT:
DISEASE(S): Colorectal Neoplasms
PROVIDER: 2187607 | ecrin-mdr-crc |
REPOSITORIES: ECRIN MDR
Similar Datasets
Project description:The purpose of this study is to determine the effect of amifostine (ETHYOL) on decreasing the rate and severity of nerve dysfunction or neuropathy (numbness and tingling in hands and feet) associated with FOLFOX chemotherapy.
| 2049589 | ecrin-mdr-crc
Project description:Interventions: The intervention involves a questionnaire that is given to patients prior to each cycle of chemotherapy which is given every 3 weeks as an outpatient at secondary hospital settings in the MidCentral Region. Patients will receive up to 8 cycles of chemotherapy.
This questionnaire is a modified version of the NCI PRO-CTCAE neurotoxicity questions. It has been modified for use in this study by also incorporating questions regarding symptom duration and persistence of symptoms. The answers to the questions are then used by the treating clinician who is either the specialist medical oncologist or the training registrar under the supervision of the medical oncologist, to modify the Oxaliplatin dose according to a pre-specified guideline which is outlined in a flow-diagram. This guideline suggests the following modifications:
* No numbness or tingling continue with same dose
* Reported mild numbness and tingling triggers a 20-25% dose reduction in Oxaliplatin for the subsequent cycle
* If a patient reports that mild numbness and tingling occurred on no more than or lasted for no longer than 3 days, the clinician has the option of continuing with the same dose of chemotherapy
* If a patient reports persistent mild numbness and tingling present at the time of clinic, this triggers a hold” on Oxaliplatin and Capecitabine continues. If the numbness or tingling improves or remains mild at the subsequent pre-chemotherapy clinic, Oxaliplatin can be reintroduced with a 20-25% dose reduction
* Reported moderate numbness and tingling triggers a hold” on Oxaliplatin for the subsequent cycle
* Capecitabine chemotherapy continues, without Oxaliplatin
* Assessment of numbness and tingling at the subsequent pre-chemotherapy clinic
* If numbness and tingling is pr
Primary outcome(s): Acceptability of the intervention defined by clinician compliance with the intervention - this will be measured as a percentage of individuals in which the intervention is implemented. This will be assessed using forms which are filled out by the clinician at clinic. The forms will ask what has the patient has recorded on their questionnaire, what modifications have been made to chemotherapy and if the intervention has not been followed, why this is. Acceptability requires that the intervention is implemented in at least 80% of individuals. [This is assessed at the completion of oxaliplatin chemotherapy, this being when the patient has stopped all oxaliplatin. Compliance is where the intervention has been followed throughout the chemotherapy course for an individual patient.
The reason for completion of chemotherapy, ie. toxicity, progression, completed all intended cycles, will be captured on forms filled out by the clinician at clinic. ]
Study Design: Purpose: Prevention; Allocation: Non-randomised trial; Assignment: Single group;Type of endpoint: Safety/efficacy
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Project description:Chemotherapy-induced peripheral neuropathy (CIPN) is a progressive, enduring, and often irreversible condition featuring pain, numbness, tingling and sensitivity to cold in the hands and feet (sometimes progressing to the arms and legs) that afflicts between 30 and 40 percent of patients undergoing chemotherapy.
American Society of Clinical Oncology (ASCO) guidance on The Journal of Clinical Oncology (JCO, 2014 April 14) does not recommend any prophylaxis regimen for CIPN.
PerOx Quench has unique membrane protection and anti-oxidative function as a special food, that’s why to try to explore its preventive effects on CIPN prevention induced by Oxaliplatin for colorectal cancer or gastric cancer chemotherapy.
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Project description:In this study the investigators will assess how useful and safe acupuncture is in easing the pain, tingling and numbness that is caused by chemotherapy. The researchers hope this will prevent the need to reduce the amount of chemotherapy a patient receives.
| 2146974 | ecrin-mdr-crc
Project description:<p>When undergoing treatment for breast cancer, many women experience severe side effects, some of which result in treatment-related death and some that can persist for years. Little is understood regarding factors that may predict drug toxicities. Pharmacogenetics, the investigation of variants in candidate genes in drug metabolism pathways, has been used to determine susceptibility to treatment-related toxicities, as well as to cancer recurrence. Although there have been some strong and important findings using this approach, such as identification of single nucleotide polymorphisms (SNPs) that predispose to side effects associated with thiopurines and irinotecan, there has been less progress in assessment of genetic variants that predispose to toxicities resulting from the multi-drug regimen commonly used to treat breast cancer, anthracyclines (A), cyclophosphamide (C), and taxanes (T). These difficulties in identification of key gene variants may be due to the complex metabolic pathways of these drugs, the lack of rate limiting enzymes in the processes, or the limitations of single SNP analysis, rather than capturing all of the variability across the genes.</p> <p>In addition to drug metabolism pathways, however, there may be a number of constitutional factors or other processes that affect damage to normal tissues in the course of chemotherapy, some known or hypothesized, such as DNA repair and oxidative stress pathways, and others not yet discovered. However, there have been no clear candidate genes that account for a large part of the variation in drug or treatment response, and there are likely important genes that influence sensitivity of cells to chemotherapy through unknown pathways which have not yet been identified or hypothesized. The present technological capabilities to screen the entire genome for variants that discriminate populations allows the opportunity to identify these as yet unknown pathways, and open the doors to exciting new avenues of research into mechanisms that had not been previously considered.</p> <p>We conducted a genome-wide scan (GWAS) in a clinical trial (S0221), in which women with high risk breast cancer were treated with different dosing schedules of C, A and T. Blood specimens were collected and banked, and DNA extracted for genotyping on the Illumina OMNI 1M platform. The GWAS data were used to examine genetic variants significantly associated with grades 3 and 4 toxicities, including peripheral neuropathy recorded during the T segment. In S0221, toxicities were graded according to the NCI Common Toxicity Criteria for Adverse Events (CTCAE). The neurotoxicity is predominantly a distal sensory neuropathy, which is characterized by pain, numbness, tingling, and reduced functional capacity in the extremities. Other symptoms include parasthesias, ataxia, impaired vibration and joint position sense, and loss of tendon reflexes. By using a GWAS approach, it is likely that important pathways not previously considered can be revealed as important in susceptibility to treatment-related toxicities, identifying those at greatest risk for alternate drugs or dose reduction, and opening new areas of research for prevention of taxanes-related neuropathy among patients receiving chemotherapy for breast cancer. </p>
| phs001428 | dbGaP
Project description:The SARS-CoV-2 has already caused over 523 million COVID-19 cases and 6.27 million deaths worldwide. COVID-19 leads to a severe acute respiratory syndrome, a hyperinflammatory response, and widespread multi-organ damage. Common symptoms of COVID-19 include fever, cough, fatigue, shortness of breath, and loss of taste and smell. Here we offer an in-depth analysis of the transcriptional response to SARS-CoV-2. We performed RNA-seq analysis of lung tissues from three COVID-19 patients.
2022-09-07 | GSE203401 | GEO
Project description:Background and study aims
Chemotherapy-induced peripheral neuropathy (CIPN) is one of the common reasons that colorectal cancer patients cannot maintain their routine chemotherapy schedules. CIPN involves pain, numbness, tingling and sensitivity to cold in the hands and feet and is often very painful and stressful. Some medications are used for pain relief, but they are often not effective. As a result, there has been renewed interest in alternative therapies that stimulate the hand muscles, such as exercise or massage to relieve the neuropathic symptoms.
This study aims to look at the effectiveness of a handicraft program as rehabilitation for colorectal cancer patients with CIPN, which involves basic craftwork to encourage the use of the minor muscles of the hands to make and decorate handicrafts.
Who can participate?
Adults with colorectal cancer who received chemotherapy
What does the study involve?
This rehabilitation program comes in the form of the handicraft class, which involves decorating crafts such as a hand mirror, a business card holder, a table clock, and a picture frame with lacquerware, using Korean traditional lacquerworks. This is performed once a week, for 2 hours per each session, for a total of 4 weeks. All volunteers will participate in same program. The effectiveness of this program will be evaluated by using a questionnaire.
| 2412118 | ecrin-mdr-crc
Project description:Interventions: Patients receiving abraxane chemotherapy for pancreatic cancer, breast cancer, colorectal cancer, non-small cell lung cancer or ovarian cancer will be recruited into the study to document the natural history of Abraxane-induced neurotoxicity through cross-sectional and prospective clinical and neurophysiological assessment. Examples of neurotoxicity seen with abraxane therapy include sensory dysasthesia including numbness and tingling in the hands and feet.
Patients will be assessed monthly from the commencement of treatment until cessation, with 3-monthly follow up 6-12 months following cessation of treatment, to a maximum period of 2 years following enrolment.
Primary outcome(s): To document the natural history of Abraxane-induced neurotoxicity through cross-sectional and prospective clinical and neurophysiological assessment.
The severity of neuropathy will be assessed using the Total Neuropathy Score (TNS). This will be used to evaluate neuropathy in a number of different categories; sensory neuropathic symptoms, examination findings and nerve conduction results.[Assessed at monthly intervals from the commencement of treatment until cessation, with 3-monthly follow up 6-12 months following cessation of treatment.]
Study Design: Purpose: Natural history;Duration: Longitudinal;Selection: Defined population;Timing: Prospective
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Project description:Irritable bowel syndrome (IBS) patients often experience meal associated symptoms. Our objective was to determine small intestinal mechanisms of lipid-induced symptoms and rectal hypersensitivity in IBS based on RNA-seq.
2022-02-28 | GSE166869 | GEO
Project description:Globally, over 65 million individuals are estimated to suffer from post-acute sequelae of COVID-19 (PASC). A large number of individuals living with PASC experience cardiovascular symptoms (i.e. chest pain and heart palpitations) (PASC-CVS). The role of chronic inflammation in these symptoms, in particular in individuals with symptoms persisting for >1 year after SARS-CoV-2 infection, remains to be determined. Here, we show that compared to individuals with a resolved SARS-CoV-2 infection (and no persistent symptoms), individuals with prolonged PASC-CVS had elevated levels of pro-inflammatory cytokines. However, these cytokines were found to be present in trace amounts, such that they could only be detected with the use of novel nanotechnology. Importantly, these trace-level cytokines had a direct effect on the functionality of primary human cardiomyocytes in vitro. Proteomics analyses demonstrated further differences in PASC-CVS and recovered plasma including increased abundance of complement and coagulation associated proteins.
2024-11-01 | PXD050202 | Pride