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Prospective Study of Laparoscopic Navigation Surgery with using Indocyanine green-labelled Omental Appendices

ABSTRACT: Interventions: ICG-labelled omental appendices Primary outcome(s): Detection rate of indocyanine green-labelled omental appendices Study Design: Single arm Non-randomized

DISEASE(S): Colorectal Cancer

PROVIDER: 2646901 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Indocyanine green (ICG) application to intraoperative navigation of fluorescence imaging

Project description:Interventions: Indocyanine green (ICG) Primary outcome(s): Adverse event Study Design: Single arm Non-randomized

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Evaluation of Lymphatic flow using indocyanine green fluorescence imaging

Project description:Interventions: Submucosal injection of indocyanine green Primary outcome(s): Distance from tumor to proximal or distal end of visualized lymphatic flow with indocyanine green fluorescence Study Design: single arm study, open(masking not used), uncontrolled control, single assignment, treatment purpose

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A Study to Evaluate the Efficacy and Safety of Local administration of Indocyanine Green in Surgery for Colorectal Neoplasm

Project description:Interventions: Off-label use of indocyanine green for detecting sentinel lymph nodes during surgery of colorectal cancer;indocyanine green Primary outcome(s): Rate of subjects with resection line changed from baseline due to ICG fluorescence Study Design: single arm study, open(masking not used), uncontrolled control, single assignment, treatment purpose

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Koeller2021 - PBPK model of ICG liver function tests

Project description:Physiollogically based pharmacokinetic (PBPK) model of indocyanine-green (ICG) liver function tests.

2023-01-18 | MODEL2301090001 | BioModels

Endoscopic Submucosal Injection of Indocyanine Green Before Laparoscopic Radical Resection for Colorectal Cancer

Project description:Prospective registry study of endoscopic submucosal injection of indocyanine green before laparoscopic radical resection for colorectal cancer

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Anastomotic Leakage and Value Of Indocyanine Green in Decreasing Leakage Rates

Project description:Anastomotic leakage (AL) is one of the major complications after gastrointestinal surgery. Compromised tissue perfusion at the anastomosis site increases the risk of AL. Indocyanine green (ICG) combined with fluorescent near infrared imaging has proven to be a feasible and reproducible application for real-time intraoperative quantification of the tissue perfusion and cohort studies showed reduced leakage rate. Unfortunately, these studies were not randomized. Therefore, we propose a nationwide randomized controlled trial to identify the value of ICG for AL in colorectal anastomosis.

| 2364100 | ecrin-mdr-crc

Application of Near Infrared-Indocyanine Green Imaging System in Robot/Laparoscopic Colorectal Cancer Surgery: A Single Center, Prospective Controlled Trial

Project description:Interventions: experimental group:application of near infrared-indocyanine green imaging system;Control group:Not use near infrared-indocyanine green imaging system Primary outcome(s): Number of lymph nodes detected and positive rate;Perfusion of anastomosis;Anastomotic leakage;Navigation of vessels and structures Study Design: Non randomized control

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Evaluation of the intestinal lymph flow and blood flow using Indocyanine green(ICG)fluorescence method in a colorectal surgery

Project description:Interventions: 1 Indocyanine green local injection at the colorectal surgery 2 Indocyanine green intravenous injection at the colorectal surgery Primary outcome(s): 1 Identification rate of lymphatic vessels and fluorescent lymph nodes near the tumor. 2 Evaluation of blood flow of the anastomotic site Study Design: Single arm Non-randomized

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Indocyanine green fluorescence navigation in laparoscopic hepatectomy: a retrospective single-center study of 120 cases.

Project description:PurposeTo explore the role of indocyanine green (ICG) fluorescence navigation in laparoscopic hepatectomy and investigate if the timing of its administration influences the intraoperative observation.MethodsThe subjects of this retrospective study were 120 patients who underwent laparoscopic hepatectomy; divided into an ICG-FN group (n = 57) and a non-ICG-FN group (n = 63). We analyzed the baseline data and operative data.ResultsThere were no remarkable differences in baseline data such as demographic characteristics, lesion-related characteristics, and liver function parameters between the groups. Operative time and intraoperative blood loss were significantly lower in the ICG-FN group. The rate of R0 resection of malignant tumors was comparable in the ICG-FN and non-ICG-FN groups, but the wide surgical margin rate was significantly higher in the ICG-FN group. The administration of ICG 0-3 or 4-7 days preoperatively did not affect the intraoperative fluorescence imaging. Operative time, intraoperative blood loss, and a wide surgical margin correlated with ICG fluorescence navigation. ICG fluorescence navigation helped to minimize intraoperative blood loss and achieve a wide surgical margin.ConclusionICG fluorescence navigation is safe and efficient in laparoscopic hepatectomy. It helps to achieve a wide surgical margin, which could result in a better prognosis. The administration of ICG 0-3 days preoperatively is acceptable.

| S-EPMC8055570 | biostudies-literature

Indocyanine green fluorescence imaging for assessing risk factors of anastomotic leakage after colorectal cancer surgery

Project description:Interventions: To assess the blood flow at anastomotic site by comparing a direct vision with that under near infrared light after intravenous infusion of indocyanine green. Primary outcome(s): Is it effective or not to assess blood flow at anastomotic site by indocyanine green fluorescent imaging? Study Design: Single arm Non-randomized

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