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Effects of depth of anesthesia monitored by index of consciousness on patients undergoing laparoscopic radical resection of colorectal cancer: a randomized controlled trial.

ABSTRACT: Interventions: Group A:IoC2 25-35;Group B:IoC2 35-45;Group C:IoC2 45-55 Primary outcome(s): dosage of remifentanil;IoC1;IoC2 Study Design: Parallel

DISEASE(S): Colorectal Cancer

PROVIDER: 2693326 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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The effect of permissive hypercapnia on delirium after laparoscopic radical resection of colorectal cancer in elderly patients: a randomized controlled trial

Project description:Interventions: N:Maintain PaCO2 at 35-45mmHg ;H:Maintain PaCO2 at 45-55mmHg ;P:Maintain PaCO2 at 55-65mmHg Primary outcome(s): Postoperative delirium;IL-1 beta, IL-6, TNF-alpha Study Design: Quasi-randomized controlled

| 2700726 | ecrin-mdr-crc

Examining the effect of the linker DNA length on protein binding to di-nucleosomes decorated with H3K9me3 and H3K27me3

Project description:Characteristic features of chromatin states are not limited to particular epigenetic modifications but include other regulatory cues, such as linker DNA length, typically ranging from between 35-55 bp (Valouev et al, 2011; Voong et al., 2016, Cell) to over 200 bp in nucleosome-depleted regions (NDRs) found at active enhancers and promoters (Schones et al, 2008; Hansen He et al, 2010). To investigate whether and how the nucleosome linker DNA affects chromatin recognition by nuclear proteins we performed a set of affinity purifications using di-nucleosomes incorporating different DNA linkers. This dataset contains experiments aimed to probe how the linker DNA length affects protein binding to di-nucleosomes decorated with H3K9me3 or H3K27me3. The following di-nucleosomes were used in affinity pull-down purifications with HeLa nuclear extract followed by label-free MS: 1. unmod. H3, 35 bp linker 2. unmod. H3, 40 bp linker 3. unmod. H3, 45 bp linker 4. unmod. H3, 50 bp linker 5. unmod. H3, 55 bp linker 6. H3K9me3, 35 bp linker 7. H3K9me3, 40 bp linker 8. H3K9me3, 45 bp linker 9. H3K9me3 50 bp linker 10. H3K9me3, 55 bp linker 11. H3K27me3, 35 bp linker 12. H3K27me3, 40 bp linker 13. H3K27me3, 45 bp linker 14. H3K27me3, 50 bp linker 15. H3K27me3, 55 bp linker

2023-12-10 | PXD042368 | Pride

The transcriptomics of SLC18A3 positive cells from arcuate nucleus of rats in different pubertal development stages.

Project description:Based on our spatial transcriptomics sequencing data, we observed solute carrier family 18 member A3 (SLC18A3) was specificially expressed in kisspeptin-expressed neurons in arcuate nucleus (ARC). SLC18A3 as a surface marker was used to examine the isolation of living kisspeptin-expressed neurons by flow cytometric (FACS) assay. Fresh isolated ARC nucleus tissues from female Sprague-Dawley rats in postnatal day (PND)-25, 35 and 45 (n=10 each group) were harvested, and processed single-cell suspension for FACS assay by SLC18A3. Here, we obtained two populations according to the cell size by FSC/SSC signals, and further harvested a small proportion of Slc18a3+ cells from hypothalamus of PND-25, 35 and 45. Smart-seq was conducted to detect the transcriptome of four population namely large Slc18a3+/- cells as well as small Slc18a3+/- cells.

2021-10-04 | E-MTAB-10975 | biostudies-arrayexpress

Effect of surgical pleth index-guided remifentanil administration on perioperative outcomes in elderly patients: a prospective randomized controlled trial

Project description:Interventions: receive remifentanil infusion guided by SPI (group S) during surgery receive remifentanil infusion guided by clinical judgement based on hemodynamic parameters (group C) during surgery Primary outcome(s): intraoperative opioid (remifentanil) consumption Study Design: Parallel Randomized

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Consistency analysis of consciousness index and bispectral index in monitoring the depth of sevoflurane anesthesia in laparoscopic surgery

Project description: Not available

| S-EPMC10874172 | biostudies-literature

Comparative Evaluation of a New Depth of Anesthesia Index in ConView® System and the Bispectral Index during Total Intravenous Anesthesia: A Multicenter Clinical Trial.

Project description:The performance of a new monitor for the depth of anesthesia (DOA), the Depth of Anesthesia Index (Ai) based on sample entropy (SampEn), 95% spectral edge frequency (95%SEF), and burst suppression ratio (BSR) was evaluated compared to Bispectral Index (BIS) during total intravenous anesthesia (TIVA). 144 patients in six medical centers were enrolled. General anesthesia was induced with stepwise-increased target-controlled infusion (TCI) of propofol until loss of consciousness (LOC). During surgery propofol was titrated according to BIS. Both Ai and BIS were recorded. Primary outcomes: the limits of agreement between Ai and BIS were -17.68 and 16.49, which were, respectively, -30.0% and 28.0% of the mean value of BIS. Secondary outcomes: prediction probability (Pk) of BIS and Ai was 0.943 and 0.935 (p=0.102) during LOC and 0.928 and 0.918 (p=0.037) during recovery of consciousness (ROC). And the values of BIS and Ai were 68.19 and 66.44 at 50%LOC, and 76.65 and 78.60 at 50%ROC. A decrease or an increase of Ai was significantly greater than that of BIS when consciousness changes (during LOC: -9.13±10.20 versus -5.83±9.63, p<0.001; during ROC: 10.88±11.51 versus 5.32±7.53, p<0.001). The conclusion is that Ai has similar characteristic of BIS as a DOA monitor and revealed the advantage of SampEn for indicating conscious level. This trial is registered at Chinese Clinical Trial Registry with ChiCTR-IOR-16009471.

| S-EPMC6425335 | biostudies-literature

Transcriptome Profile of Near-isogenic Soybean Lines for α-Subunit Deficiency during Seed Maturation

Project description:To identify α-null-related transcriptional changes, the gene expressions of cgy-2-NIL and its recurrent parent DN47 were compared using Illumina high-throughput RNA-sequencing on samples at 25, 35, 50, and 55 days after flowering (DAF). Seeds at 18 DAF served as the control.

2017-02-11 | GSE79327 | GEO

Biphasic functional regulation in hippocampus of rat with chronic cerebral hypoperfusion induced by permanent occlusion of bilateral common carotid artery

Project description:We measured temporal changes of gene expression in hippocampus of rat after BCCAo using time-course microarray analysis Total RNA from the hippocampus from each time point of 21, 35, 45, 55 and 70 days after the BCCAo were subject to microarray.

2013-02-14 | E-GEOD-44289 | biostudies-arrayexpress

The clinical trial of opioid-sparing anesthesia undergoing major laparoscopic abdominal surgery

Project description:Interventions: Remifentanil group:Remifentanil continuous infused with 0.2-0.5ug/kg/h;Low-opioid anesthesia group:Esketamine and dexmedetomidine continuous infused with 0.2-0.5ug/kg/h Primary outcome(s): Postoperative numeric rating scale pain score Study Design: Parallel

| 40173 | ecrin-mdr-crc

Gene expression data from spinal cord of DRa1-mMOG-35-55 or Vehicle treated DR*1501-Tg mice with EAE

Project description:To evaluate DRα1-mMOG-35-55 effects on CNS inflammation during Experimental allergic encephalomyelitis (EAE) in a more comprehensive manner, we performed microarray analysis on spinal cords from DRα1-mMOG-35-55- vs. Vehicle-treated DR*1501-Tg mice with EAE. EAE was induced with mMOG-35-55/CFA/Ptx and mice were treated with DRα1-mMOG-35-55 (100ug daily x 3) or Vehicle ,after disease onset at a clinical score of 2. Twenty four hr after the last treatment, total RNA was isolated from spinal cords and gene expression profiles from pooled RNA were analyzed using the Mouse Gene 2.0 ST Affymetrix GeneChip system

2015-05-13 | GSE68805 | GEO

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