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The mechanism research of ANK3 in colorectal cancer

ABSTRACT: Interventions: The cancer group:Detection of ANK3 expression Primary outcome(s): Detection of ANK3 expression Study Design: Non randomized control

DISEASE(S): Colorectal Cancer

PROVIDER: 41569 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Sugarcane drought experiment under field conditions

Project description:A field experiment was conducted at the Federal University of Alagoas in Maceio, Brazil. varieties RB86-7515, RB85-5536 and RB92-579 were distributed in a randomized block design with four replicates in two conditions: irrigated (control) and non-irrigated (treatment).

2021-01-14 | GSE125070 | GEO

Clinical research and the mechanism of Cinobufotalin combination chemotherapy prevent the relapse and metastasis of colorectal cancer

Project description:Interventions: Trial group :Cinobufotalin combination chemotherapy ;Control:Chemotherapy Primary outcome(s): routine blood test;Urine routine test;Fecal routine test;Fecal occult blood;Liver and kidney function;Immune functionCD3?CD4;Tumor markers CA199, CEA, CA50, CA125;TCM Syndrome Rating Scale;Piper Fatigue Scale Study Design: Randomized parallel controlled trial

| 2666613 | ecrin-mdr-crc

The mechanism research of the effect of high fat and abnormal metabalism of intestinal microflora on the risk of colorectal cancer

Project description:Interventions: diet intervention:reduce calorie intake;probiotics intervention:take probiotics;combined intervention:reduce calorie intake&take probiotics;no intervention:nothing Primary outcome(s): detection of intestinal flora;detection of blood;incidence of colorectal cancer Study Design: Randomized parallel controlled trial

| 2675455 | ecrin-mdr-crc

Control run hybridization

Project description:Laboratory strain poliovirus was hybridized to the array as a control run and a proof of concept. Degree of cross hybridization between polio nucleic acid and non-polio probes was evaluated. Specificity of the probe design was determined. Keywords: control study: target detection and specificity

2008-02-28 | GSE10566 | GEO

Myositis

Project description:Idiopathic inflammatory myopathies (polymyositis and dermatomyositis) are heterogeneous group of muscle disorders of unknown etiology.The pathogenic pathways responsible for muscle fiber damage and dysfunction in myositis are not currently well defined. Identification of such pathways may help to design novel therapeutic interventions and also help to develop diagnostic tests. Keywords: Development or differentiation design

2006-07-21 | GSE5370 | GEO

EFFECT OF ORAL UREA SUPPLEMENTATION ON THE ENDOMETRIAL TRANSCRIPTOME OF MARES

Project description:At ovulation detection (D0), oral treatment with urea was initiated and continued until D7. Mares received a treatment or control diet (n= 11 mares/group) in a crossover design. The treated group received urea (0.4 g/kg body weight) mixed with sweet feed and molasses, the control group received sweet feed and molasses alone. Blood samples were collected daily, one hour after feeding, for BUN determination. Uterine and vaginal pH were evaluated with an epoxy pH probe. Endometrial biopsies were taken transcervically one hour after the last feeding on D7. RNA sequencing of the endometrium of a subset of mares (n=6/group) was conducted.

2022-07-08 | GSE133973 | GEO

Genomic profile of maize response to A. flavus infection identifies genes associated with biotic and abiotic resistance

Project description:The experiment consisted of a field design containing two maize inbred lines Va35 and Mp313E. Va35 has yellow kernels and is susceptible to kernel infection by Aspergillus flavus (A. flavus). Mp313E is a white dent maize inbred line and was released primarily as a source of resistance to kernel infection by A. flavus. The test ears were inoculated with Aspergillus flavus and collected two days after inoculation. Non-inoculated ears collected 16 days after pollination were also used as a control. The microarray experimental design was a randomized complete block design with three replications. One microarray slide was used for each field plot. Each slide contained the inoculated and non-inoculated sub-treatments. A second slide for one replication of each genotype contained a dye swap for the inoculation treatment and three subsamples (dots) within the slide represented each contig. Keywords: Direct comparison

2007-11-09 | GSE9546 | GEO

NimbleGen Sequence Capture Array in A549 cells after 125I seed irradiation

Project description:Purpose:To investigate the biological behavior on the invation, proliferation, and apoptosis, and the molecular mechanism of A549 cell which induced by 125I seed irradiation. Design:The first part cell Experiment: cultured A549 cell in vitro, then divided into 125I seeds group and control group. Using MTT, Transwell experiment, flow cytometric analysis the difference among cell proliferation, invasion, and apoptosis, after 125I seeds different treatment time on the A549 cell. Nimblegen human genome microarray detection to find out the genes expression changes between the two groups. Then screen out target gene, using protein chip technology and western-blot further verified target gene protein expression.

2020-10-23 | GSE159431 | GEO

Transcription profiling of human airway epithelial cells in asthmatics, smokers and healthy controls

Project description:We collected airway epithelial brushings for microarray analysis from 42 asthmatics and two control groups â 28 healthy subjects and 16 smokers. A subgroup of 32 asthmatics completed a randomized placebo-controlled trial of fluticasone propionate in which collection of brushings was repeated after 1 week of treatment. Experiment Overall Design: 1) Comparison of gene expression in asthmatics to healthy controls Experiment Overall Design: 2) Comparison of smokers to healthy controls Experiment Overall Design: 3) Comparison of change in gene expression in the fluticasone treated group to the change in the placebo treated group

2008-06-13 | E-GEOD-4302 | biostudies-arrayexpress

Anti-cancer drug sensitive DNA methylation marker research

Project description:Genome wide DNA methylation profiling of normal and colon cancer and assosiation study between anti-cancer drug respond group and non-respond group. The Illumina Infinium 27k Human DNA methylation Beadchip v1.2 was used to obtain DNA methylation profiles across approximately 27,000 CpGs in 118 paired anti-cancer drug response tested colon cancer and adjacent normal tissues

2011-12-31 | GSE27130 | GEO

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