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Feasibility and cost analysis of post-polypectomy trauma opening in patients with colorectal cancer: a multicenter, prospective, cohort study protocol

ABSTRACT: Interventions: control group (retrospective):wound closure;experimental group:wound opening Primary outcome(s): Incidence of delayed bleeding after polypectomy Study Design: Single arm

DISEASE(S): Intestinal Polyps

PROVIDER: 81172 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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The investigation of prophylactic clip hemorrhage control for colorectal cold snare polypectomy in patients taking anti-thrombotic drugs.

Project description:Interventions: Patients who meet the inclusion criteria and do not meet the exclusion criteria are randomly assigned 1:1 to the clip closure group or the non-clip closure group. Hematochezia will be evaluated in a patient diary for 2 weeks after the cold snare polypectomy.;D016430;CSP clip Antithrombotics Primary outcome(s): Percentage of delayed bleeding within 2 weeks after CSP (per patient). Delayed bleeding is defined as hematochezia requiring endoscopic hemostasis within 2 weeks after CSP. Study Design: randomized controlled trial, open(masking not used), no treatment control/standard of care control, parallel assignment, treatment purpose

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Efficacy and safety of cold polypectomy for colorectal polyps : a prospective randomized study

Project description:Interventions: Conventional polypectomy Cold polypectomy Primary outcome(s): The incidence of delayed bleeding Study Design: Parallel Randomized

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Effects of prophylactic clip closure versus non-closure after colorectal endoscopic submucosal dissection on postoperative outcomes: A phase III prospective randomized controlled trial

Project description:Interventions: closure group non-closure group Primary outcome(s): delayed bleeding rate (severe) delayed bleeding rate (mild) Study Design: Parallel Randomized

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Transcriptomic characterization of the delayed wound healing response in a diabetic skin humanized mice model

Project description:Previously, we developed a new model of diabetes-induced wound healing impairment in skin-humanized mice models that faithfully recapitulates the major histo-physiological features of such skin repair-deficient condition. Aiming to dissect the molecular mechanisms responsible for the delayed wound closure, global gene expression studies were performed.

2021-02-01 | GSE147890 | GEO

Efficacy of complete clip closure of the mucosal defect after colorectal-ESD : A randomized controlled, multicenter trial (CCC trial)

Project description:Interventions: without clip closure after ESD complete clip closure after ESD Primary outcome(s): Delayed adverse event rates (Post-ESD coagulation syndrome, delayed bleeding, delayed perforation), intention to treat analysis Study Design: Parallel Randomized

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A multicenter prospective study of the efficacy of prophylactic clip closure for prevention of delayed bleeding after colorectal ESD (endoscopic submucosal dissection)

Project description:Interventions: Prophylactic clip closure after colorectal ESD Primary outcome(s): The rate of delayed bleeding after prophylactic clip closure Study Design: Single arm Non-randomized

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Project description:flower opening and closure in waterlily

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Characterization of wound healing in Atlantic salmon (Salmo salar) post-smolt, and the effect of stress on the healing process

Project description:The aim of this study was to assess the effect induced by high fish density on cutaneous wound healing in post-smolt Atlantic salmon. Our findings suggest that high fish density enhances inflammation and represses cell proliferation, tissue secretion and collagen synthesis in the healing wounds. These processes are further manifested in the different layers of the skin, such as delayed re-epithelialization, altered mucus response, reduced scale mineralization, enhanced wound pigmentation and delayed organization of dense connective tissue. Temporarily changes in wound healing mechanisms result in permanent differences in wound contraction. In conclusion, our results show that high fish density dispose the fish for an enhanced immune response and delayed tissue repair, which ultimately results in delayed wound healing.

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Evaluation of usefulness of prophylactically hemostatic clipping for artificial ulcers after cold snare polypectomy for colonic polyps

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Evaluation of Nexpowder Application to Prevent Delayed Bleeding After Colorectal Endoscopic Mucosal Resection

Project description:Delayed bleeding is the most frequent (5 to 15%) and challenging complication after large colorectal polypectomy. Different preventive treatments, such as the prophylactic use of clips, have been tried to prevent the occurrence of delayed bleeding, but to date, no treatment has clearly shown its effectiveness. In addition, preventive hemostasis with clips is difficult and costly. A newly developed endoscopic hemostatic powder generating gelation effect (Nexpowder) may be an effective alternative to prevent post polypectomy bleeding in patients treated by endoscopic mucosal resection (EMR) for large superficial colorectal lesions.

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