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ZBTB24 is a transcriptional regulator that coordinates with DNMT3B to control DNA methylation

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE111689 | GEO | 2018/07/31

REPOSITORIES: GEO

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ZBTB24 is a transcriptional regulator that coordinates with DNMT3B to control DNA methylation.

Project description:The interplay between transcription factors and epigenetic writers like the DNA methyltransferases (DNMTs), and the role of this interplay in gene expression, is being increasingly appreciated. ZBTB24, a poorly characterized zinc-finger protein, or the de novo methyltransferase DNMT3B, when mutated, cause Immunodeficiency, Centromere Instability, and Facial anomalies (ICF) syndrome, suggesting an underlying mechanistic link. Chromatin immunoprecipitation coupled with loss-of-function approaches in model systems revealed common loci bound by ZBTB24 and DNMT3B, where they function to regulate gene body methylation. Genes coordinately regulated by ZBTB24 and DNMT3B are enriched for molecular mechanisms essential for cellular homeostasis, highlighting the importance of the ZBTB24-DNMT3B interplay in maintaining epigenetic patterns required for normal cellular function. We identify a ZBTB24 DNA binding motif, which is contained within the promoters of most of its transcriptional targets, including CDCA7, AXIN2, and OSTC. Direct binding of ZBTB24 at the promoters of these genes targets them for transcriptional activation. ZBTB24 binding at the promoters of RNF169 and CAMKMT, however, targets them for transcriptional repression. The involvement of ZBTB24 targets in diverse cellular programs, including the VDR/RXR and interferon regulatory pathways, suggest that ZBTB24's role as a transcriptional regulator is not restricted to immune cells.

| S-EPMC6212772 | biostudies-literature

ZBTB24 is a transcriptional regulator that coordinates with DNMT3B to control DNA methylation [Infinium]

Project description:The interplay between transcription factors and epigenetic writers like the DNA methyltransferases (DNMTs), and the role of this interplay in modulating gene expression, is being increasingly appreciated. We investigated the interplay between ZBTB24, a zinc-finger protein belonging to the BTB-POZ family of transcription factors, and the de novo DNA methyltransferase DNMT3B. Both factors, when mutated, cause Immunodeficiency, Centromere Instability, and Facial anomalies (ICF) syndrome, suggesting they are mechanistically linked in some way, but almost nothing is known about ZBTB24. In this study, we identified genomic targets regulated by ZBTB24, and identified its recognition motif, binding to which leads to activation. Chromatin immunoprecipitation in model cell line systems revealed common genes bound by ZBTB24 and DNMT3B, where they function to regulate gene body methylation. Genes coordinately regulated by ZBTB24 and DNMT3B are enriched for molecular mechanisms essential for cellular homeostasis, highlighting the importance of the ZBTB24-DNMT3B interplay in maintaining epigenetic patterns required for normal cellular function.

2018-07-31 | GSE111681 | GEO

ZBTB24 is a transcriptional regulator that coordinates with DNMT3B to control DNA methylation [ChiP-Seq and RNA-Seq]

2018-08-01 | GSE111683 | GEO

ZBTB24 is a transcriptional regulator that coordinates with DNMT3B to control DNA methylation

Project description:ZBTB24 is a transcriptional regulator that coordinates with DNMT3B to control DNA methylation

| PRJNA437878 | ENA

ZBTB24 is a transcriptional regulator that coordinates with DNMT3B to control DNA methylation [Infinium]

Project description:ZBTB24 is a transcriptional regulator that coordinates with DNMT3B to control DNA methylation [Infinium]

| PRJNA437864 | ENA

Increased DNA Methylation of Dnmt3b-Targets Impairs Leukemogenesis

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2016-01-11 | E-GEOD-71041 | biostudies-arrayexpress

ZBTB24 is a transcriptional regulator that coordinates with DNMT3B to control DNA methylation [ChiP-Seq and RNA-Seq]

Project description:ZBTB24 is a transcriptional regulator that coordinates with DNMT3B to control DNA methylation [ChiP-Seq and RNA-Seq]

| PRJNA438030 | ENA

PRC2 coordinates lineage fidelity and DNA methylation during ESC differentiation

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2014-11-17 | E-GEOD-53508 | biostudies-arrayexpress

Increased DNA Methylation of Dnmt3b-Targets Impairs Leukemogenesis

Project description:This SuperSeries is composed of the SubSeries listed below.

2016-01-11 | GSE71041 | GEO

DNA methylation as a transcriptional regulator of the immune system.

Project description:DNA methylation is a dynamic epigenetic modification with a prominent role in determining mammalian cell development, lineage identity, and transcriptional regulation. Primarily linked to gene silencing, novel technologies have expanded the ability to measure DNA methylation on a genome-wide scale and uncover context-dependent regulatory roles. The immune system is a prototypic model for studying how DNA methylation patterning modulates cell type- and stimulus-specific transcriptional programs. Preservation of host defense and organ homeostasis depends on fine-tuned epigenetic mechanisms controlling myeloid and lymphoid cell differentiation and function, which shape innate and adaptive immune responses. Dysregulation of these processes can lead to human immune system pathology as seen in blood malignancies, infections, and autoimmune diseases. Identification of distinct epigenotypes linked to pathogenesis carries the potential to validate therapeutic targets in disease prevention and management.

| S-EPMC6331288 | biostudies-literature

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