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Shh is a determinant of gammadelta T-cell development in the thymus

ABSTRACT: We compared gammadelta T-cell development and subsets in the thymus of mice in which Shh had been conditionally deleted from thymic epithelial cells using FoxN1-Cre to WT mice, and to transgenic mice in which a constitutively activator (Gli2DN2) or constitutuvely repressor (Gli2DC2) form of Gli2 were expressed under the control of the lck-promotor. We sorted CD27+CD3+TCR-gammadelta+ cells from 4 week old mice and comapred gene expression by RNAsequencing. All mice were on a C57BL/6 background.

ORGANISM(S): Mus musculus

PROVIDER: GSE113468 | GEO | 2021/04/20

REPOSITORIES: GEO

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