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Molecular Pathology of adverse local tissue reaction caused by metal-on-metal implants

ABSTRACT: RNA-sequencing analysis of periacetabular synovial tissue collected from patients undergoing a revision total hip arthroplasty (rTHA) after failure of a Cobalt Chromium implant. Comparisons were made to periacetabular synovial tissue collected from patients undergoing primary THAs (pTHA). Results: Analysis of tissue biopsies by RNA-sequencing revealed that MoM patient samples exhibit significantly increased expression of immune response genes but decreased expression of genes related to extracellular matrix (ECM) remodeling.

ORGANISM(S): Homo sapiens

PROVIDER: GSE119331 | GEO | 2019/01/01

REPOSITORIES: GEO

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