Gene expression comparison of resting human peripheral-blood NK cells and activated counterparts

ABSTRACT: Resting NK cells are notoriously difficult to transduce, especially using the VSVG lentivirus pseudotype. When NK cells are expanded and activated using the NKAES system, there is a modest improvement of transduction rates compared to their resting NK counterparts. Still, the transduction efficiency remains poor for robust development of NK cell-based cancer immunotherapy. We envisaged to have a genome-wide expression profile of resting and activated NK (NKAES) cells in order to improve currrent transduction protocols .

ORGANISM(S): Homo sapiens

PROVIDER: GSE128696 | GEO | 2019/11/28

REPOSITORIES: GEO