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TooManyCells identifies and visualizes relationships of single-cell clades

ABSTRACT: Purpose: To characterize heterogeneity of GSI-responsive and -resistant T-ALL cells Method: We generated GSI-resistant T-ALL DND41 cells and profiled their transcriptome using single-cell RNA sequencing. Result: We report here the presence of resistant-like subpopulation in drug naïve DND41 T-ALL cells. Conclusion: While other popular scRNA-seq clustering algorithms failed, TooManyCells, a suite of clustering and visualization algorithm developed in our lab, could identify rare resistant-like DND41 T-ALL cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE138892 | GEO | 2020/01/15

REPOSITORIES: GEO

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