Genomics

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Genome-wide maps of chromatin state in WT c-Myc and K427R mutant lymphoma cells


ABSTRACT: We report the application of single-molecule-based sequencing technology for high-throughput profiling of  c-Myc with core promoters of its target genes  in mammalian cells. We performed ChIP sequencing with antibody to total c-Myc with core promoters of its target genes in WT c-Myc and K427R mutant group. Inspection of multiple individual traces and global analyses showed that the K427R mutant globally reduced association of c-Myc with core promoters of its target genes.

ORGANISM(S): Homo sapiens

PROVIDER: GSE143864 | GEO | 2020/10/10

REPOSITORIES: GEO

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