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Profiling the response of scalp hair follicles to short-term treatment with hepatocyte growth factor

ABSTRACT: Hepatocyte growth factor (HGF) is a well-known promoter of cell proliferation, morphogenesis, migration, angiogenesis and pigmentation. To characterize its effects on human scalp dissected hair follicles, we performed gene expression profiling on RNA isolated from entire hair follicles, comparing the effects of 6hr HGF treatment versus control. 183 genes were differentially up-/down-regulated compared to vehicle control. These genes were involved in a number of different biological pathways suggesting that HGF can have various effects upon human hair follicle function.

ORGANISM(S): Homo sapiens

PROVIDER: GSE151560 | GEO | 2023/05/29

REPOSITORIES: GEO

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