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Genome-wide identification of target genes for the transcription factor Sox10 in the Msc80 Schwann cell line.

ABSTRACT: To identify target genes of the Sox10 transcription factor in peripheral glia in a genome-wide and unbiased approach, we performed CRISPR/Cas9-dependent genome editing of the mouse Sox10 gene in the Msc80 Schwann cell line, followed by RNA-Seq studies on Sox10-expressing control Msc80 cells and Sox10-negative genome edited cell clones. Among others we detected substantial changes in the expression of genes associated with Schwann cell adhesion and the formation of the node of Ranvier.

ORGANISM(S): Mus musculus

PROVIDER: GSE152687 | GEO | 2021/06/01

REPOSITORIES: GEO

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