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HOXD13 Suppresses Prostate Cancer Metastasis and BMP4-induced EMT by Inhibiting SMAD1

ABSTRACT: HOX genes regulate organ development and their abrrative expressions are also implicated in cancer progressions. It is a universal strategy for tumors to regain cell plasticity through disruption of Hox boundaries. Along with this clue, we identified HOXD13 as a pivotal component since HOXD13 deprivation alone is enough to induce more aggressive phenotypes in prostate cancer cells. Here we subjected HOXD13 manipulated prostate cancer cells (LNCaP) to HiSeq RNA-Seq to identify its target genes involved in the antitumor activity.

ORGANISM(S): Homo sapiens

PROVIDER: GSE162947 | GEO | 2021/01/20

REPOSITORIES: GEO

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