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Transcriptomic profiles of type I/III interferon-responsive hair follicle subsets from ROSA26YFP_Mx1 and ADAM10;ROSA26YFP_Mx1mice

ABSTRACT: Inflammation triggered by viral infections can obscure tissue function. We utilized a model of systemic anti-viral immunity and found that the ADAM10-Notch signaling axis in type I/III interferon-responsive upper hair follicles (HF) was crucial for the expression of genes that regulated skin microbiota and protected HFs and its stem cell niche from inflammatory destruction.

ORGANISM(S): Mus musculus

PROVIDER: GSE180798 | GEO | 2021/07/26

REPOSITORIES: GEO

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