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Germline-like TCR alpha chains dominate shared self-reactive T cell receptors in type 1 diabetes

ABSTRACT: Human islet antigen reactive CD4+ memory T cells (IAR T cells) play a key role in the pathogenesis of autoimmune type 1 diabetes (T1D). Using single cell RNA-sequencing (scRNA-seq) to identify T cell receptors (TCRs) in IAR T cells, we have identified a class of TCRs that share TCR alpha chains between individuals (“public”).

ORGANISM(S): Homo sapiens

PROVIDER: GSE182870 | GEO | 2021/12/15

REPOSITORIES: GEO

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