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Gene expression based, effect of DNA minor groove binding ligand on human cells in response to ionizing radiation

ABSTRACT: Radiation induced DNA damage initiates a complex series of overlapping responses responsible for the maintenance of genome integrity. The data reports the expression analysis in response to DNA minor groove binding ligand with an emphasis on its ability to afford better protection in cells exposed to ionizing radiation.

ORGANISM(S): Homo sapiens

PROVIDER: GSE18422 | GEO | 2010/11/01

SECONDARY ACCESSION(S): PRJNA118219

REPOSITORIES: GEO

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Gene expression based, effect of DNA minor groove binding ligand on human cells in response to ionizing radiation

Project description:Radiation induced DNA damage initiates a complex series of overlapping responses responsible for the maintenance of genome integrity. The data reports the expression analysis in response to DNA minor groove binding ligand with an emphasis on its ability to afford better protection in cells exposed to ionizing radiation. Four different types if samples were employed in analysis- Control i.e. untreated cells, 50ÂµM ligand treated cells, 8.5Gy radiation treated cells, cells treated with 50ÂµM ligand one hour prior to irradiation.

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To study the molecular mechanism of DNA minor groove binding ligand as a radiaiton modulator

Project description:Radiation induced DNA damage initiates a complex series of overlapping responses responsible for the maintenance of genome integrity. The data reports the expression analysis in response to DNA minor groove binding ligand with an emphasis on its ability to afford better protection in cells exposed to ionizing radiation. Four different types if samples were employed in analysis- Control i.e. untreated cells, 50ÂµM ligand treated cells, 2Gy radiation treated cells, cells treated with 50ÂµM ligand one hour prior to 2 Gy irradiation.

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Molecular mechanism of DNA minor groove binding ligand as a radiation modulator

Project description:Radiation-induced DNA damage initiates a complex series of overlapping responses responsible for the maintenance of genome integrity. This study reports the expression analysis in response to DNA minor groove binding ligand (DMA-5-(4-methylpiperazin-1-yl)-2-[2’-(3,4-dimethoxyphenyl)-5`-benzimidazolyl] benzimidazole, an analogue of Hoechst 33342), with an emphasis on its ability to afford better protection in cells exposed to ionizing radiation. Four different types of samples were employed in the analysis: Control (untreated) cells, 50µM ligand-treated cells, 2Gy radiation-treated cells, and cells treated with 50µM ligand one hour prior to 2Gy irradiation.

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Differential gene expression after gamma radiation in bis-benzimidazole-treated human glioblastoma using microarray analysis

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Project description:Radiation-induced DNA damage initiates a complex series of overlapping responses responsible for the maintenance of genome integrity. This study reports the expression analysis in response to DNA minor groove binding ligand (DMA-5-(4-methylpiperazin-1-yl)-2-[2’-(3,4-dimethoxyphenyl)-5`-benzimidazolyl] benzimidazole, an analogue of Hoechst 33342), with an emphasis on its ability to afford better protection in cells exposed to ionizing radiation. Four different types of samples were employed in the analysis: Control (untreated) cells, 50µM ligand-treated cells, 8.5Gy radiation-treated cells, and cells treated with 50µM ligand one hour prior to irradiation.

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Tardigrades dramatically upregulate DNA repair pathway genes in response to ionizing radiation

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The HRP3 PWWP domain recognizes the minor groove of double-stranded DNA and recruits HRP3 to chromatin

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