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Transcriptome analysis of liver tumors derived from human induced liver cancer-forming cells (iLCCs)

ABSTRACT: We found that a set of six transcription factors, FOXA3, HNF1A, HNF1B, LIN28B, L-MYC, and KLF5, can induce direct conversion of human umbilical vein endothelial cells (HUVECs) into liver cancer-forming cells (LCCs). These induced LCCs (iLCCs) efficiently give rise to tumors that closely resemble human combined hepatocellular cholangiocarcinoma after transplantation to immunodeficient mice. We conducted RNA-seq analyses to investigate the characteristincs of the tumors derived from iLCCs.

ORGANISM(S): Homo sapiens

PROVIDER: GSE184539 | GEO | 2022/02/27

REPOSITORIES: GEO

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