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Role of FGF-2 induced non-coding RNA in cancer [II]

ABSTRACT: We show that IER3 and IER3-AS1 protein coding and non-coding genes mediates oncogenic properties in cancer cell lines when they are induced by FGF-2 which is fibroblast growth factor. Comprehensive analysis of mechanisms behind the regulation of these genes by FGF-2 induction is shown in this study.

ORGANISM(S): Homo sapiens

PROVIDER: GSE190211 | GEO | 2022/06/24

REPOSITORIES: GEO

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Role of FGF-2 induced non-coding RNA in cancer [I]

Project description:We show that IER3 and IER3-AS1 protein coding and non-coding genes mediates oncogenic properties in cancer cell lines when they are induced by FGF-2 which is fibroblast growth factor. Comprehensive analysis of mechanisms behind the regulation of these genes by FGF-2 induction is shown in this study.

2022-06-24 | GSE189962 | GEO

Role of hnRNPK in FGF-2 induced non-coding RNA in cancer

Project description:We show that IER3 and IER3-AS1 protein coding and non-coding genes mediates oncogenic properties in cancer cell lines when they are induced by FGF-2 which is fibroblast growth factor. Mechanistic studies show that these two RNAs are regulated by hnRNPK. Hence, we investigated the role of hnRNPK by knocking down this gene and studying the changes in the global targets including IER3 and IER3-AS1.

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Project description:Characterisation IER3-AS1 interacting proteins using chromatin oligo-affinity precipitation (ChOP) followed by mass spectrometry. The HeLa cell lysates was incubated with biotinylated antisense oligonucleotides (ASO), targeting an experimental target antisense long noncoding RNA IER3-AS1 or a control RNA LacZ. LacZ and IER3-AS1 interacting proteomes were pulldown using Streptavidin beads. The eluted protein samples from both LacZ control ASOs and IER3-AS1 ASOs subjected to mass-spectrometry analyses to identify IER3-AS1 interacting proteins.

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Role of FGF-2 induced non-coding RNA in cancer [II]

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