Transcriptional alteration in malaria parasite after disruption of PfPRMT5 [Array]

ABSTRACT: Purpose: this study is to analyze the change of overall transctiption after disruption of Protein Arginine Methyltranferase 5 (PRMT5) in Plasmodium falciparum. Methods: In this study, the transcriptomes of a PfPRMT5 gene knockout (KO) parasite line with its wildtype control were analyzed a custom-desinged Agilent microarray.Total RNA were harvested from the asexual parasites at four stages (ring, early trophozoite, late trophozoite, and schizont)(12h, 24h, 36h, and 46h post-invasion) using the Quick-RNA MiniPrep kit (Zymo Research).

ORGANISM(S): Plasmodium falciparum

PROVIDER: GSE199419 | GEO | 2023/06/28

REPOSITORIES: GEO