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Hepatic responses of mice and rats to equivalent acetaminophen (APAP) insult [rat]

ABSTRACT: The well-known difference in sensitivity of mice and rats to acetaminophen (APAP) liver injury has been related to differences in the fraction that is bioactivated to the reactive metabolite N-acetyl-p-benzoquinoneimine (NAPQI). Physiologically-based pharmacokinetic modelling was used to identify doses of APAP (300 and 1000 mg/kg in mice and rats, respectively) yielding similar hepatic burdens of NAPQI, to enable the comparison of temporal liver tissue responses under conditions of equivalent chemical insult.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE205202 | GEO | 2023/06/20

REPOSITORIES: GEO

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Hepatic responses of mice and rats to equivalent acetaminophen (APAP) insult [mouse]

Project description:The well-known difference in sensitivity of mice and rats to acetaminophen (APAP) liver injury has been related to differences in the fraction that is bioactivated to the reactive metabolite N-acetyl-p-benzoquinoneimine (NAPQI). Physiologically-based pharmacokinetic modelling was used to identify doses of APAP (300 and 1000 mg/kg in mice and rats, respectively) yielding similar hepatic burdens of NAPQI, to enable the comparison of temporal liver tissue responses under conditions of equivalent chemical insult.

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Hepatic responses of mice and rats to equivalent acetaminophen (APAP) insult

Project description:This SuperSeries is composed of the SubSeries listed below.

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