SHARE-seqV2 for single-cell epigenomic and transcriptomic mapping of human hematopoiesis at scale

ABSTRACT: A growing body of single-cell multi-omic tools enables a better understanding of gene regulation underlying development and disease. Tools mapping chromatin and gene expression (such as SHARE-seq) are limited in sensitivity and scalability. Here, we describe SHARE-seqV2 and its associated cloud-computing resource, enabling single-cell analysis at improved quality, robustness, and scale. We apply SHARE-seqV2 across various cell lines, primary tissues, and immune cells, demonstrating a generalizable platform for single-cell multi-omics.

ORGANISM(S): Mus musculus Homo sapiens

PROVIDER: GSE207308 | GEO | 2022/10/04

REPOSITORIES: GEO