Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Comparative Epigenomic Analysis of Murine and Human Adipogenesis

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

OTHER RELATED OMICS DATASETS IN: PRJNA129565PRJNA126099PRJNA129563PRJNA125035PRJNA129561PRJNA126097PRJNA129567

ORGANISM(S): Mus musculus Homo sapiens

PROVIDER: GSE20752 | GEO | 2010/09/30

SECONDARY ACCESSION(S): PRJNA125035

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Comparative transcriptomic and epigenomic analyses reveal new regulators of murine brown adipogenesis

Project description:This SuperSeries is composed of the SubSeries listed below.

2016-12-31 | GSE75698 | GEO

Comparative epigenomic analysis of murine and human adipogenesis.

Project description:We report the generation and comparative analysis of genome-wide chromatin state maps, PPAR? and CTCF localization maps, and gene expression profiles from murine and human models of adipogenesis. The data provide high-resolution views of chromatin remodeling during cellular differentiation and allow identification of thousands of putative preadipocyte- and adipocyte-specific cis-regulatory elements based on dynamic chromatin signatures. We find that the specific locations of most such elements differ between the two models, including at orthologous loci with similar expression patterns. Based on sequence analysis and reporter assays, we show that these differences are determined, in part, by evolutionary turnover of transcription factor motifs in the genome sequences and that this turnover may be facilitated by the presence of multiple distal regulatory elements at adipogenesis-dependent loci. We also utilize the close relationship between open chromatin marks and transcription factor motifs to identify and validate PLZF and SRF as regulators of adipogenesis.

| S-EPMC2950833 | biostudies-literature