Transcriptomics

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Effect of CWG-cPIP on alternative splicing defects in CUG mouse brain

ABSTRACT: CWG-cPIP targets CAG/CTG (CWG) triplet repeat DNA to inhibit the transcription in a repeat length-dependent manner. To investigate effects of CWG-cPIP on alternative splicing defects in the brain of CUG300 mice, which we developed as a model of DM1, CWG-cPIP (83 ug/kg) was injected into mouse hippocampus. RNA sequencing analysis was performed using mouse hippocampus 10 days later.

ORGANISM(S): Mus musculus

PROVIDER: GSE210837 | GEO | 2023/10/11

REPOSITORIES: GEO

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