Transcriptomics

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Off-target effect of CWG-cPIP on gene expression of mouse hippocampus

ABSTRACT: CWG-cPIP targets CAG/CTG (CWG) triplet repeat DNA to inhibit the transcription in a repeat length-dependent manner. To investigate off-target effects of CWG-cPIP on gene expression in the brain, CWG-cPIP (83 ug/kg) was injected into mouse hippocampus. RNA sequencing analysis was performed using vehicle- or CWG-cPIP-injected mouse hippocampus 3 weeks later, mixing with ERCC RNA spike-in controls.

ORGANISM(S): Mus musculus

PROVIDER: GSE235801 | GEO | 2023/10/11

REPOSITORIES: GEO

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