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Effect of CWG-cPIP on transcriptome defects in CUG mouse brain

ABSTRACT: Effect of CWG-cPIP on transcriptome defects in CUG mouse brain

PROVIDER: PRJNA867696 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR20992963_1.fastq.gz	Fastqsanger.gz
	SRR20992963_2.fastq.gz	Fastqsanger.gz
	SRR20992964_1.fastq.gz	Fastqsanger.gz
	SRR20992964_2.fastq.gz	Fastqsanger.gz
	SRR20992965_1.fastq.gz	Fastqsanger.gz

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Effect of CWG-cPIP on transcriptome defects in CUG mouse brain

Project description:CWG-cPIP targets CAG/CTG (CWG) triplet repeat DNA to inhibit the transcription in a repeat length-dependent manner. To investigate effects of CWG-cPIP on transcriptome defects in the brain of CUG300 mice, which we developed as a model of DM1, CWG-cPIP (83 ug/kg) was injected into mouse hippocampus. RNA sequencing analysis was performed using mouse hippocampus 10 days later.

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Project description:CWG-cPIP targets CAG/CTG (CWG) triplet repeat DNA to inhibit the transcription in a repeat length-dependent manner. To investigate off-target effects of CWG-cPIP on gene expression in the brain, CWG-cPIP (83 ug/kg) was injected into mouse hippocampus. RNA sequencing analysis was performed using vehicle- or CWG-cPIP-injected mouse hippocampus 3 weeks later, mixing with ERCC RNA spike-in controls.

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