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Effect of CWG-cPIP on alternative splicing defects in CUG mouse brain

ABSTRACT: Effect of CWG-cPIP on alternative splicing defects in CUG mouse brain

PROVIDER: PRJNA867695 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR20992978_1.fastq.gz	Fastqsanger.gz
	SRR20992978_2.fastq.gz	Fastqsanger.gz
	SRR20992979_1.fastq.gz	Fastqsanger.gz
	SRR20992979_2.fastq.gz	Fastqsanger.gz
	SRR20992980_1.fastq.gz	Fastqsanger.gz

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Effect of CWG-cPIP on alternative splicing defects in CUG mouse brain

Project description:CWG-cPIP targets CAG/CTG (CWG) triplet repeat DNA to inhibit the transcription in a repeat length-dependent manner. To investigate effects of CWG-cPIP on alternative splicing defects in the brain of CUG300 mice, which we developed as a model of DM1, CWG-cPIP (83 ug/kg) was injected into mouse hippocampus. RNA sequencing analysis was performed using mouse hippocampus 10 days later.

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