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Gene expression profile at single-cell level of human Simpson-Golabi-Behdel syndrome (SGBS) cells undergoing adipogenesis following knock-down of target genes using CRISPRi

ABSTRACT: CROP-Seq combines gene silencing using CRISPR interference (CRISPRi) with single-cell RNA sequencing (scRNA-Seq) in a functional reverse genetic screen. Here, we applied the CROP-Seq approach to study the function of novel genes acting in human adipogenesis or adipocyte biology that were derived from genome-wide association studies (GWAS).

ORGANISM(S): Homo sapiens

PROVIDER: GSE217812 | GEO | 2022/11/15

REPOSITORIES: GEO

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