Transcriptomics

Dataset Information

0

A mixture of chemicals found in human amniotic fluid disrupts brain gene expression and behavior in Xenopus laevis


ABSTRACT: We hypothesized that embryonic exposure to a mixture of chemicals (containing phenols, phthalates, pesticides, heavy metals, and perfluorinated, polychlorinated, and polybrominated compounds) identified as commonly found in the human amniotic fluid (as calculated in Fini et al., ) could lead to altered brain development. We assessed its effect on TH signaling and neuro-development in an amphibian model (Xenopus laevis) highly sensitive to thyroid disruption. Fertilized eggs were exposed for eight days to either TH (thyroxine, T4 10 nM) or the amniotic mixture (at the actual concentration) until reaching stage NF47, where we analyzed gene expres-sion in the brains of exposed tadpoles using both RT-qPCR and RNA sequencing.

ORGANISM(S): Xenopus laevis

PROVIDER: GSE223829 | GEO | 2023/01/27

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2023-03-11 | PXD037858 | Pride
2015-04-12 | E-GEOD-67780 | biostudies-arrayexpress
2017-01-01 | GSE73326 | GEO
2024-07-18 | PXD047061 | Pride
2023-12-20 | PXD033091 | Pride
2021-12-09 | PXD028154 | Pride
2015-04-12 | GSE67780 | GEO
2007-05-12 | GSE7051 | GEO
2024-09-06 | GSE276178 | GEO
2023-09-01 | GSE219130 | GEO