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Transcriptome profiling of OCT4 positive spermatogonia in wild type and Akt1s1 null mutant mice.

ABSTRACT: In order to investigate the regulatory roles of AKT1S1 during mouse spermatogenesis, we analyzed gene expression changes that caused by the deletion of Akt1s1 gene in mouse male germ cells using RNA sequencing method. The transcriptome profiling analyses showed that OCT4+ spermatogonia from mice at different ages possess varied changes in gene expression due to the deletion of Akt1s1 gene, supporting the role of AKT1S1 plays in mediating AKT-mTORC1 signaling during mouse spermatogenesis.

ORGANISM(S): Mus musculus

PROVIDER: GSE226181 | GEO | 2024/02/26

REPOSITORIES: GEO

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