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Changes in gene expression within the skin caused by antigen-specific memory CD4+ T cells during Vaccinia virus infection.

ABSTRACT: To investigate the mechanisms used by memory CD4+ T cells to protect the skin from poxvirus infection, we infected LCMV immune mice with VacV on the right ear skin and VacV expressing the dominant MHC-II restricted epitope from LCMV (VacV-Ii-GP61) on the left ear skin. On day 3 after the co-infection, RNA from whole skin was isolated and gene expression was analyzed using RNA sequencing.

ORGANISM(S): Mus musculus

PROVIDER: GSE227917 | GEO | 2023/03/24

REPOSITORIES: GEO

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Profiling whole-tissue metabolic reprogramming during cutaneous poxvirus infection and clearance

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