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Reactivity-Based RNA Profiling (RBRP) determined transcriptome interactions of small molecule drugs

ABSTRACT: We developed Reactivity-Based RNA Profiling (RBRP) approach to determine the off-target transcriptome interactions of small molecule drugs. Deep sequencing was used to locate and quantify drug-promoted acylation of RNA 2´-hydroxyl groups as a proxy of RNA-drug interaction in HEK293.

ORGANISM(S): Homo sapiens

PROVIDER: GSE229331 | GEO | 2023/04/13

REPOSITORIES: GEO

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