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Single-cell sequencing of 12 PBMC samples to study the different immune response after SARS-CoV-2 vaccines injection

ABSTRACT: The effectiveness of SARS-CoV-2 vaccines varies among individuals. In the COVID-19 global pandemic, it showed a significant Th1 characteristics, suggesting that the immune disorder and production of SARS-CoV-2 antibodies may be related to Th1/Th2 bias. However, the molecular mechanisms of how Th1/Th2 bias affects the differences in host immune responses to viruses remain unclear. A total of 3 subjects with elevated antibody (E) and 3 without changes (C) were recruited. We collected peripheral blood and performed single-cell sequencing before and after the third dose of SARS-CoV-2 vaccine. The changes of T cell clusters were analyzed and differential analysis of T cells between the two groups was performed.

ORGANISM(S): Homo sapiens

PROVIDER: GSE244173 | GEO | 2023/11/29

REPOSITORIES: GEO

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