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Biomarker discovery in paired mid luteal endometrial biopsies

ABSTRACT: Cell state determination is apparent within the endometrium during the mid-luteal window of implantation. Using previously identified biomarkers of cell states (SCARA5 and DIO2) we performed bulk RNA sequencing on 6 pairs of endometrial biopsies characterised by either normal biomarker expression in both biopsies, or abnormal biomarker expression in one biopsy (low SCARA5 and high DIO2) and normal expression in a second biopsy. We demonstrate that “abnormal cycles” are associated with a distinct gene expression profile when compared to “normal cycles” and have utilised this dataset for biomarker discovery.

ORGANISM(S): Homo sapiens

PROVIDER: GSE245963 | GEO | 2024/10/21

REPOSITORIES: GEO

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