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Over-expression of FLI1 in the epithelial cell line HaCaT increased expression of inflammatory markers associated with psoriasis

ABSTRACT: Friend virus induced leukemia-1 (Fli-1) is a ETS related oncogenic transcription factor initially identified by our group as a target of retroviral insertional mutagenesis in erythroleukemia induced by Friend virus. This oncogene is also activated through translocation (EWS-FLI1) or overexpression in various human solid and liquid tumors. In addition to cancer, FLI1 is involved in the development of various illnesses including inflammatory diseases. While overexpression of Fli-1 contributes to the development of autoimmune systemic lupus erythematosus (SLE), loss of this transcription factor in fibroblasts underlines systemic sclerosis. Finally, Fli-1 is also a major regulator of immunity, hematopoiesis and stem cell maintenance and developmen. Previously, we used RNAseq data of FLI1-depleted human leukemic cells and identified a correlation between FLI1 deficiency and reduced expression of markers of psoriasis. Accordingly, overexpression of FLI1 in the epithelial cell line HaCaT increased expression of these markers of inflammation and psoriasis.

ORGANISM(S): Homo sapiens

PROVIDER: GSE248221 | GEO | 2023/11/25

REPOSITORIES: GEO

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