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Emx2 underlies the development and evolution of marsupial gliding membranes

ABSTRACT: We study the genomic and developmental basis of the mammalian gliding membrane, or patagium, an adaptative trait that has repeatedly evolved in different lineages, including in closely related marsupial species. Through comparative genomic analysis of fifteen new marsupial genomes, both from gliding and non-gliding species, we find that the Emx2 locus experienced lineage-specific patterns of accelerated cis-regulatory evolution in gliding species. We confirm our finding via epigenomics, transcriptomics, and in vivo marsupial transgenics.

ORGANISM(S): Pseudocheirus peregrinus Dactylopsila trivirgata Phalanger gymnotis Petauroides volans Tarsipes rostratus Pseudocheirus occidentalis Macropus giganteus Pseudochirops cupreus Distoechurus pennatus Macropus fuliginosus Pseudochirops archeri Pseudochirops corinnae Acrobates pygmaeus Petaurus breviceps Vombatus ursinus

PROVIDER: GSE256507 | GEO | 2024/05/22

REPOSITORIES: GEO

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