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Effect of SMARCA4 knockdown on repeat elements in senescent IMR90 ER:RAS cells

ABSTRACT: We report the analysis of RNA sequencing aimed at understanding the effects induced by the knockdown of SMARCA4 on the expression of repeat and transposable elements in senescent cells. SMARCA4 was initially identified as a target through a genetic screening process designed to locate regulators responsible for upregulating SASP. SMARCA4 is a constituent of the SWI/SNF complex subunit. The findings will help characterise he expression of repeat elements to elucidate the pathway by which SMARCA4 knockdown can promote cytokine expression and Natural Killer cell recruitment.

ORGANISM(S): Homo sapiens

PROVIDER: GSE276746 | GEO | 2024/09/19

REPOSITORIES: GEO

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Effect of SMARCA4 knockdown on senescent IMR90 ER:RAS cells

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