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Aging modifies endometrial dendritic cell function and unconventional double negative T cells in the human genital mucosa.

ABSTRACT: Immune function in the genital mucosa balances reproduction with protection against pathogens. As women age, genital infections, and gynecological cancer risk increase, however, the mechanisms that regulate cell-mediated immune protection in the female genital tract and how they change with aging remain poorly understood. Unconventional double negative (DN) T cells (TCRαβ + CD4-CD8-) are thought to play important roles in reproduction in mice but have yet to be characterized in the human female genital tract. Using genital tissues from women (27–77 years old), here we investigated the impact of aging on the induction, distribution, and function of DN T cells throughout the female genital tract.

ORGANISM(S): Homo sapiens

PROVIDER: GSE279408 | GEO | 2024/11/08

REPOSITORIES: GEO

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