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Gene expression in liver of mice fed a high-fat, high-sucrose diet

ABSTRACT: We have employed whole genome microarray expression profiling in the liver of mice fed a high-fat, high-sucrose diet for 15 weeks to search genes with N-terminal signal sequences whose expression is altered concomitantly with changes in islet size. At 15 weeks, this analysis revealed a significant >4-fold upregulation in 118 genes and downregulation by >75% in 22 genes encoding putative secreted factors in liver of mice fed a HFHS, although few changes (<2-fold upregulated or >one-half downregulated) were observed at 10 weeks. Expression of four genes (NRG1, GPNMB, SERPINB1 and HGF) from this signature was quantified in the different RNA samples by real-time PCR, confirming low variability between mice.

ORGANISM(S): Mus musculus

PROVIDER: GSE282007 | GEO | 2025/01/14

REPOSITORIES: GEO

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