Transcriptomics

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Gene expression profiling of archival tongue carcinoma and normal tongue tissue (subset)


ABSTRACT: RNA extracted from 78 FFPE tongue samples, 62 tongue carcinomas and 16 non-malignant controls, were succesfully analysed using the whole genome DASL array to obtain gene expression profiles. Gene expression profiles were used to identify differentially expressed genes with the ultimate goal of finding out their importance for tongue cancer development and maintenance. Sample were formalin fixed paraffin embedded biopsies taken for diagnostic purposes and had been stored between 1 and 13 years. Because of the general poor quality of RNA from archival samples a special focus were put on its effect on the detected expression levels. 28 tumours and 16 controls with a CTdiff< 5 were selected for differential gene expression analysis. Raw data for only these samples were normalized again. Data for these 44 samples can be found here.

ORGANISM(S): Homo sapiens

PROVIDER: GSE34106 | GEO | 2012/05/11

SECONDARY ACCESSION(S): PRJNA156489

REPOSITORIES: GEO

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