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Exploration of genes expression with a DNA microarray Cancerochip.

ABSTRACT: Our goal was to search for new molecular markers of the mitochondrial implication in the thyroid tumorigenesis. Using a DNA microarray (Cancerochip), we explored a collection of thyroid samples representing 4 classes of thyroid tumors.

ORGANISM(S): Homo sapiens

PROVIDER: GSE37017 | GEO | 2012/07/01

SECONDARY ACCESSION(S): PRJNA157843

REPOSITORIES: GEO

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Exploration of genes expression with a DNA microarray Cancerochip.

Project description:Our goal was to search for new molecular markers of the mitochondrial implication in the thyroid tumorigenesis. Using a DNA microarray (Cancerochip), we explored a collection of thyroid samples representing 4 classes of thyroid tumors. 45 thyroid tumoral and paired control tissues representing 4 classes (benign follicular tumors [FTA], oncocytic variants of follicular tumors [OT], papillary thyroid carcinomas [PTC] and tumors of uncertain malignancy potential [TUMP]) of thyroid tumors were explored for the expression of 6866 genes.

2012-06-30 | E-GEOD-37017 | biostudies-arrayexpress

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The ERRalpha metabolic nuclear receptor controls growth of colon cancer cells

Project description:Estrogen-Related Receptor alpha (ERRα) is a nuclear receptor that acts principally as a regulator of metabolism processes particularly in tissues subjected to high-energy demand. Besides its implication in energy metabolism and mitochondrial biogenesis, ERRα was recently associated with tumorigenesis. Notably, increased expression of ERRα was noted in different cancerous tissues as breast, ovary and colon. However, supplemental studies are required to better understand the role of ERRα in colon carcinoma. We used microarrays to detail gene expression during ERRalpha knockdown in HCT116 cells and identified distinct classes of up and down-regulated genes.

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The ERRalpha metabolic nuclear receptor controls growth of colon cancer cells

Project description:Estrogen-Related Receptor alpha (ERRÎ±) is a nuclear receptor that acts principally as a regulator of metabolism processes particularly in tissues subjected to high-energy demand. Besides its implication in energy metabolism and mitochondrial biogenesis, ERRÎ± was recently associated with tumorigenesis. Notably, increased expression of ERRÎ± was noted in different cancerous tissues as breast, ovary and colon. However, supplemental studies are required to better understand the role of ERRÎ± in colon carcinoma. We used microarrays to detail gene expression during ERRalpha knockdown in HCT116 cells and identified distinct classes of up and down-regulated genes. Triplicate of HCT116 cell line was infected witn shscrambled(shCTL) and shERRalpha lentivirus and used for RNA extraction and hybridization on Affymetrix microarrays.

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