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Effect of dietary supplementation with Curcuma longa (turmeric) during Eimeria maxima and Eimeria tenella infection of chickens

ABSTRACT: This study utilized comparative global gene expression microarray analysis to evaluate the effects of curcumin on intestinal immunity of chicken.

ORGANISM(S): Gallus gallus

PROVIDER: GSE37813 | GEO | 2012/05/08

SECONDARY ACCESSION(S): PRJNA163867

REPOSITORIES: GEO

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Effect of dietary supplementation with Curcuma longa (turmeric) during Eimeria maxima and Eimeria tenella infection of chickens

Project description:This study utilized comparative global gene expression microarray analysis to evaluate the effects of curcumin on intestinal immunity of chicken. Two-condition experiment, Curcumin-fed chickens vs. Non-treated control chickens. Biological replicates: 2 control replicates, 2 Curcumin-fed replicates with dye-switching.

2012-05-07 | E-GEOD-37813 | biostudies-arrayexpress

Effect of dietary supplementation with Anethol during Eimeria maxima and Eimeria tenella infection of chickens

Project description:This study utilized comparative global gene expression microarray analysis to evaluate the effects of Anethol on intestinal immunity of chicken.

2012-10-02 | GSE41250 | GEO

Effect of dietary supplementation with Anethol during Eimeria maxima and Eimeria tenella infection of chickens

Project description:This study utilized comparative global gene expression microarray analysis to evaluate the effects of Anethol on intestinal immunity of chicken. Two-condition experiment, Anethol-fed chickens vs. Non-treated control chickens. Biological replicates: 2 control replicates, 2 Anethol-fed replicates with dye-switching.

2012-10-02 | E-GEOD-41250 | biostudies-arrayexpress

Improved resistance to Eimeria acervulina infection in chickens due to dietary supplementation with garlic metabolites

2012-03-07 | GSE36302 | GEO

Improved resistance to Eimeria acervulina infection in chickens due to dietary supplementation with garlic metabolites

Project description:This study utilized comparative global gene expression microarray analysis to evaluate the effects of a compound including garlic-derived secondary metabolites on intestinal immunity of chicken. Two-condition experiment, Garlic metabolites-fed chickens vs. Non-treated control chickens. Biological replicates: 2 control replicates, 2 Garlic metabolites-fed replicates with dye-switching.

2012-03-07 | E-GEOD-36302 | biostudies-arrayexpress

Transgenic Eimeria tenella Expressing Profilin of Eimeria maxima Elicits Enhanced Protective Immunity and Alters Gut Microbiome of Chickens.

Project description:Coccidiosis is one of the most serious diseases of livestock and birds in the world. Vaccination with live-parasite anticoccidial vaccines with genetic manipulation improving the immunogenicity of vaccine strains would be the best means for controlling coccidiosis in breeder and layer stocks, even in fast-growing broilers. Profilin from apicomplexan parasites is the first molecularly defined ligand for Toll-like receptor 11 (TLR11) and TLR12 in mice and is a potential molecular adjuvant. Here, we constructed a transgenic Eimeria tenella line (Et-EmPro) expressing the profilin of Eimeria maxima, the most immunogenic species of chicken coccidia, and evaluated the adjuvant effects of EmPro on the immunogenicity of E. tenella We found that immunization with the transgenic Eimeria parasites, compared with the wild type, elicited greater parasite antigen-specific cell-mediated immunity, characterized by increased numbers of interferon gamma (IFN-γ)-secreting lymphocytes. The transgenic parasite also induced better protective immunity against E. tenella challenge than the wild type. In addition, the diversity of the fecal microbiome of the birds immunized with the transgenic parasite differed from that of the microbiome of the wild-type-immunized birds, indicating interactions of Eimeria with the gut microbiome of chickens. Our results showing enhanced immunogenicity of E. tenella by use of EmPro as a molecular adjuvant derived from the most immunogenic affinis species represent a large step forward in the development of the next generation of coccidiosis vaccines using Eimeria as a vaccine platform expressing molecular adjuvants and potentially other pathogen antigens against not only coccidiosis but also other infectious diseases.

| S-EPMC6105905 | biostudies-literature

Effect of dietary supplementation with direct fed microbials (DFM) in chicken

Project description:This study utilized comparative global gene expression microarray analysis to evaluate the effects of DFM on intestinal immunity of chicken.

2012-11-01 | GSE41934 | GEO

Effect of dietary supplementation with direct fed microbials (DFM) in chicken

Project description:This study utilized comparative global gene expression microarray analysis to evaluate the effects of DFM on intestinal immunity of chicken. Two-condition experiment, DFM-fed chickens vs. Non-treated control chickens. Biological replicates: 2 control replicates, 2 DFM-fed replicates with dye-switching.

2012-11-01 | E-GEOD-41934 | biostudies-arrayexpress

Liver-expressed antimicrobial peptide-2 is downregulated in Eimeria maxima-infected chickens

Project description:Avian coccidiosis is a major disease of poultry caused by the intestinal protozoa Eimeria. Aviagen line A and line B birds show differential susceptibility to Eimeria infection, with line B birds exhibiting higher lesion scores and mortality. The objective of this study was to examine differential intestinal gene expression between line A and B chicks in response to a challenge with Eimeria maxima. Following challenge with 1 x 10^4 oocysts/chick, greater than 40% of line A chicks had lesion scores of 0 to 1 (on 0 to 4 scale), similar to controls. In contrast, all line B challenged chicks at this same dose had lesion scores of 2 to 4.

2011-07-01 | GSE25588 | GEO

Comparative analysis of chicken Intestinal Intraepithelial lymphocytes (IEL) following Eimeria acervulina (EA), E. maxima (EM), or E. tenella (ET) infection

Project description:Relative expression levels of mRNAs in chicken IEL experimentally infected with EA, EM, or ET were measured at 1 to 6 days post-infection (dpi) following primary and secondary infections. One week-old chickens were uninfected (negative control) or were orally inoculated with sporulated oocysts of EA, EM, or ET. One week later, the infected chickens were challenged with an identical inoculum of the homologous parasite. Intestinal samples were collected daily from 5 birds in a treatment group at from 1 to 6 dpi following primary and secondary infections. Cecum, duodenum, and jejunum were collected from the birds challenged with E. acervulina, E. maxima, and E. tenella, respectively. Uninfected control samples and one of the 3 infection group samples were labeled with different fluorescent dyes and hybridized simultaneously on the same slide using a reference design with a dye swap protocol.

2011-08-15 | GSE31213 | GEO

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