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Effect of dietary supplementation with Curcuma longa (turmeric) during Eimeria maxima and Eimeria tenella infection of chickens

ABSTRACT: This study utilized comparative global gene expression microarray analysis to evaluate the effects of curcumin on intestinal immunity of chicken.

ORGANISM(S): Gallus gallus

PROVIDER: GSE37813 | GEO | 2012/05/08

SECONDARY ACCESSION(S): PRJNA163867

REPOSITORIES: GEO

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Effect of dietary supplementation with Curcuma longa (turmeric) during Eimeria maxima and Eimeria tenella infection of chickens

Project description:This study utilized comparative global gene expression microarray analysis to evaluate the effects of curcumin on intestinal immunity of chicken. Two-condition experiment, Curcumin-fed chickens vs. Non-treated control chickens. Biological replicates: 2 control replicates, 2 Curcumin-fed replicates with dye-switching.

2012-05-07 | E-GEOD-37813 | biostudies-arrayexpress

Effect of dietary supplementation with Anethol during Eimeria maxima and Eimeria tenella infection of chickens

Project description:This study utilized comparative global gene expression microarray analysis to evaluate the effects of Anethol on intestinal immunity of chicken.

2012-10-02 | GSE41250 | GEO

Effect of dietary supplementation with Anethol during Eimeria maxima and Eimeria tenella infection of chickens

Project description:This study utilized comparative global gene expression microarray analysis to evaluate the effects of Anethol on intestinal immunity of chicken. Two-condition experiment, Anethol-fed chickens vs. Non-treated control chickens. Biological replicates: 2 control replicates, 2 Anethol-fed replicates with dye-switching.

2012-10-02 | E-GEOD-41250 | biostudies-arrayexpress

Improved resistance to Eimeria acervulina infection in chickens due to dietary supplementation with garlic metabolites

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Improved resistance to Eimeria acervulina infection in chickens due to dietary supplementation with garlic metabolites

Project description:This study utilized comparative global gene expression microarray analysis to evaluate the effects of a compound including garlic-derived secondary metabolites on intestinal immunity of chicken. Two-condition experiment, Garlic metabolites-fed chickens vs. Non-treated control chickens. Biological replicates: 2 control replicates, 2 Garlic metabolites-fed replicates with dye-switching.

2012-03-07 | E-GEOD-36302 | biostudies-arrayexpress

Transgenic Eimeria tenella Expressing Profilin of Eimeria maxima Elicits Enhanced Protective Immunity and Alters Gut Microbiome of Chickens.

Project description:Coccidiosis is one of the most serious diseases of livestock and birds in the world. Vaccination with live-parasite anticoccidial vaccines with genetic manipulation improving the immunogenicity of vaccine strains would be the best means for controlling coccidiosis in breeder and layer stocks, even in fast-growing broilers. Profilin from apicomplexan parasites is the first molecularly defined ligand for Toll-like receptor 11 (TLR11) and TLR12 in mice and is a potential molecular adjuvant. Here, we constructed a transgenic Eimeria tenella line (Et-EmPro) expressing the profilin of Eimeria maxima, the most immunogenic species of chicken coccidia, and evaluated the adjuvant effects of EmPro on the immunogenicity of E. tenella We found that immunization with the transgenic Eimeria parasites, compared with the wild type, elicited greater parasite antigen-specific cell-mediated immunity, characterized by increased numbers of interferon gamma (IFN-γ)-secreting lymphocytes. The transgenic parasite also induced better protective immunity against E. tenella challenge than the wild type. In addition, the diversity of the fecal microbiome of the birds immunized with the transgenic parasite differed from that of the microbiome of the wild-type-immunized birds, indicating interactions of Eimeria with the gut microbiome of chickens. Our results showing enhanced immunogenicity of E. tenella by use of EmPro as a molecular adjuvant derived from the most immunogenic affinis species represent a large step forward in the development of the next generation of coccidiosis vaccines using Eimeria as a vaccine platform expressing molecular adjuvants and potentially other pathogen antigens against not only coccidiosis but also other infectious diseases.

| S-EPMC6105905 | biostudies-literature

Effect of dietary supplementation with direct fed microbials (DFM) in chicken

Project description:This study utilized comparative global gene expression microarray analysis to evaluate the effects of DFM on intestinal immunity of chicken.

2012-11-01 | GSE41934 | GEO

Effect of dietary supplementation with direct fed microbials (DFM) in chicken

Project description:This study utilized comparative global gene expression microarray analysis to evaluate the effects of DFM on intestinal immunity of chicken. Two-condition experiment, DFM-fed chickens vs. Non-treated control chickens. Biological replicates: 2 control replicates, 2 DFM-fed replicates with dye-switching.

2012-11-01 | E-GEOD-41934 | biostudies-arrayexpress

Liver-expressed antimicrobial peptide-2 is downregulated in Eimeria maxima-infected chickens

Project description:Avian coccidiosis is a major disease of poultry caused by the intestinal protozoa Eimeria. Aviagen line A and line B birds show differential susceptibility to Eimeria infection, with line B birds exhibiting higher lesion scores and mortality. The objective of this study was to examine differential intestinal gene expression between line A and B chicks in response to a challenge with Eimeria maxima. Following challenge with 1 x 10^4 oocysts/chick, greater than 40% of line A chicks had lesion scores of 0 to 1 (on 0 to 4 scale), similar to controls. In contrast, all line B challenged chicks at this same dose had lesion scores of 2 to 4.

2011-07-01 | GSE25588 | GEO

Identification of common immunodominant antigens of Eimeria tenella, Eimeria acervulina and Eimeria maxima by immunoproteomic analysis.

Project description:Clinical chicken coccidiosis is mostly caused by simultaneous infection of several Eimeria species, and host immunity against Eimeria is species-specific. It is urgent to identify common immunodominant antigen of Eimeria for developing multivalent anticoccidial vaccines. In this study, sporozoite proteins of Eimeria tenella, Eimeria acervulina and Eimeria maxima were analyzed by two-dimensional electrophoresis (2DE). Western bot analysis was performed on the yielded 2DE gel using antisera of E. tenella E. acervulina and E. maxima respectively. Next, the detected immunodominant spots were identified by comparing the data from MALDI-TOF-MS/MS with available databases. Finally, Eimeria common antigens were identified by comparing amino acid sequence between the three Eimeria species. The results showed that analysis by 2DE of sporozoite proteins detected 629, 626 and 632 protein spots from E. tenella, E. acervulina and E. maxima respectively. Western bot analysis revealed 50 (E. tenella), 64 (E. acervulina) and 57 (E. maxima) immunodominant spots from the sporozoite 2DE gels of the three Eimeria species. The immunodominant spots were identified as 33, 27 and 25 immunodominant antigens of E. tenella, E. acervulina and E. maxima respectively. Fifty-four immunodominant proteins were identified as 18 ortholog proteins among the three Eimeria species. Finally, 5 of the 18 ortholog proteins were identified as common immunodominant antigens including elongation factor 2 (EF-2), 14-3-3 protein, ubiquitin-conjugating enzyme domain-containing protein (UCE) and glyceraldehyde-3-phosphate dehydrogenase (GAPDH). In conclusion, our results not only provide Eimeria sporozoite immunodominant antigen map and additional immunodominant antigens, but also common immunodominant antigens for developing multivalent anticoccidial vaccines.

| S-EPMC5471023 | biostudies-literature

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