Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Expression data from odontogenic epithelial cells

ABSTRACT: The aim to the study was to elucidate the character of odontogenic epithelial cells from epithelial cell rests of Malassez in comparison with gingival epithelial cells by carrying out a geome-wide expression analysis.

ORGANISM(S): Homo sapiens

PROVIDER: GSE75085 | GEO | 2015/11/18

SECONDARY ACCESSION(S): PRJNA302433

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Expression data from Clear cell odontogenic carcinoma cell line

Project description:The aim to the study was to elucidate the character of Clear cell odontogenic carcinoma cell line in comparison with mucoepidermoid carcinoma cell line by carrying out a geome-wide expression analysis.

2016-07-13 | GSE84300 | GEO

Expression data from odontogenic tumours

Project description:The aim of the study was to elucidate the cellular origin of ameloblastoma and keratocystic odontogenic tumour, neoplasms believed to arise from dental epithelial cells, by carrying out a genome-wide expression analysis.

2014-12-02 | GSE38494 | GEO

Expression data from Periostin isoform 3 and 6 overexpressing oral cancer cells

Project description:The aim to the study was to elucidate the character of Periostin isoform 3 and 6 by carrying out a geome-wide expression analysis.

2019-01-31 | GSE125874 | GEO

Wnt/β-catenin signaling, which is activated in odontomas, reduces Sema3A expression to regulate odontogenic epithelial cell proliferation and tooth germ development

Project description:Odontomas are classified as odontogenic benign tumors, which show disorganized dental mineralized hard tissue formation in the jaw, but mechanisms in the induction of odontomas remain to be clarified. Odontomas are also thought to be developmental anomalies of tooth germ, which frequently occur in patients with familial adenomatous polyposis (FAP) involving activation of Wnt/b-catenin signaling. However, the roles of Wnt/b-catenin signaling in odontomas or odontogenic cells remain to be clarified. The current study was conducted to investigate the expression of b-catenin in odontomas and the function of Wnt/b-catenin signaling in odontogenic epithelial cells and tooth germ development. b-catenin frequently accumulated in the nucleus and/or cellular cytoplasm of remaining odontogenic epithelial cells in human odontoma specimens, immunohistochemically. Activation of Wnt/b-catenin signaling inhibited odontogenic epithelial cell proliferation and mouse tooth germ development, while inducing epithelial bud formation in the novel developed epithelial tooth bud culture system derived from mouse tooth germ. We identified Semaphorin 3A (Sema3A) as a downstream molecule of Wnt/b-catenin signaling using DNA microarray analysis and showed that Wnt/b-catenin signaling-dependent reduction of Sema3A expression resulted in suppression of odontogenic epithelial cell proliferation. Novel developed epithelial tooth bud culture system revealed that Sema3A expression is required in epithelial budding morphogenesis. These results suggest that Wnt/b-catenin signaling negatively regulates odontogenic epithelial cell proliferation and tooth germ development through decreased-Sema3A expression, and aberrant activation of Wnt/b-catenin signaling may be associated with the formation of odontomas.

2019-03-20 | GSE116739 | GEO

Effects of endogenous GDF11 on the odontogenic differentiation of dental pulp stem cells

Project description:Knockdown of endogenous GDF11 downregulated the odontogenic differentiation of human dental pulp stem cells (hDPSCs). We performed RNA-seq analysis on hDPSCs transfected with GDF11 small interfering RNA (siRNA) and control siRNA after 7 days of odontogenic induction, in order to investigate the underlying mechanisms of endogenous GDF11 regulating odontogenic differentiation in hDPSC.

2020-06-03 | GSE151435 | GEO

RNA-seq analyses of human ameloblastoma and odontogenic keratocyst

Project description:Ameloblastoma (AM) is a benign but locally invasive tumor with high recurrence rates. Invasive behavior of the odontogenic tumor results in destruction of the adjacent jawbone and formation of daughter cysts, hindering the complete elimination of cancer cells during surgery. To understand the underlying mechanism of AM invasion, we compared the transcriptome of AM with that of an odontogenic keratocyst (OKC), a dental epithelium-originated cyst with non-invasive characteristics.

2022-05-02 | GSE186489 | GEO

Effect of P. gingivalis on human primary gingival epithelial cells

Project description:EXPERIMENT: Microarray expression profiles derived from the human primary gingival epithelial cells 24.0h after exposure to heat inactivated P. gingivalis ANIMAL MODEL: NON EXPOSURE: Human primary gingival epithelial cells (at 3rd passage) were exposed to heat inactivated P. gingivalis (MOI:100) at 90% confluence. Two types of gingival epithelial cells were used. One with Normal cytokine inducer type (at least 2 fold IL-6/TNF-alpha/IL-1Ã when challenged with TLR2/4 agonists) and the other with diminished cytokine inducer type (no change in IL-6/TNF-alpha/IL-1Ã when challenged with TLR2/4 agonists). INTERVAL: NON. PLATFORM: microRNA expression profile in gingival epithelial cells - miRCURY LNAâ¢ microRNA Arrays (Exiqon). The RNA samples were subjected to microarray on 8/9/2007 Keywords = Human primary gingival epithelial cells Keywords = P. gingivalis Keywords = Periodontitis Keywords: Ordered The effect of heat inactivated P. gingivalison human primary gingival epithelial cells were assayed.

2010-05-16 | E-GEOD-13042 | biostudies-arrayexpress

Whole transcriptomes analyses of control and Rictor knockout intestinal epithelial cells

Project description:To explore the molecular mechanisms of mTORC2, RNA sequencing was performed to analyze the geome-wide change of Rictor knockout intestinal epithelial cells compared to those of control intestinal epithelial cells.

2024-09-21 | GSE243343 | GEO

Remission for loss of odontogenic potential in a new micromilieu in vitro

Project description:During embryonic organogenesis, the odontogenic potential resides in dental mesenchyme from the bud stage until birth. Mouse dental mesenchymal cells (mDMCs) isolated from the inductive dental mesenchyme of developing molars are frequently used in the context of tooth development and regeneration. cultured mDMCs could retain the odontogenic potential for 24 h with a ratio of 60% for tooth formation, but mDMCs were incapable of supporting tooth formation after more than 24 h in culture. To reveal the underlying mechanism of the impairment of odontogenic potential, we generated gene expression profiles from mDMCs in culture using RNA-seq.

2016-10-31 | GSE78228 | GEO

Effect of P. gingivalis on human primary gingival epithelial cells

Project description:EXPERIMENT: Microarray expression profiles derived from the human primary gingival epithelial cells 24.0h after exposure to heat inactivated P. gingivalis ANIMAL MODEL: NON EXPOSURE: Human primary gingival epithelial cells (at 3rd passage) were exposed to heat inactivated P. gingivalis (MOI:100) at 90% confluence. Two types of gingival epithelial cells were used. One with Normal cytokine inducer type (at least 2 fold IL-6/TNF-alpha/IL-1ß when challenged with TLR2/4 agonists) and the other with diminished cytokine inducer type (no change in IL-6/TNF-alpha/IL-1ß when challenged with TLR2/4 agonists). INTERVAL: NON. PLATFORM: microRNA expression profile in gingival epithelial cells - miRCURY LNA™ microRNA Arrays (Exiqon). The RNA samples were subjected to microarray on 8/9/2007 Keywords = Human primary gingival epithelial cells Keywords = P. gingivalis Keywords = Periodontitis Keywords: Ordered

2008-11-07 | GSE13042 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data